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Title Handbook of Analysis of Oligonucleotides and Related Products
Published CRC Press 2011
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Description 1 online resource (511)
Contents Ch. 1. Purity analysis and impurities determination by reversed-phase high-performance liquid chromatography / Hagen Cramer, Kevin J. Finn, and Eric Herzberg -- ch. 2. Purity analysis and impurities determination by AEX-HPLC / Jim Thayer, Veeravagu Murugaiah, and Yansheng Wu -- ch. 3. Purity analysis and molecular weight determination by size exclusion HPLC / Ming Fai Chan and Ipsita Roymoulik -- ch. 4. Analysis of oligonucleotides by liquid chromatography and mass spectrometry / Soheil Pourshahian and Sean M. McCarthy -- ch. 5. Sequence determination and confirmation by MS/MS and MALDI-TOF / Zoltan Timar -- ch. 6. Tm analysis of oligonucleotides / Huihe Zhu and G. Susan Srivatsa -- ch. 7. Purity and content analysis of oligonucleotides by capillary gel electrophoresis / Judy Carmody and Bernhard Noll -- ch. 8. Bioanalysis of therapeutic oligonucleotides using hybridization-based immunoassay techniques / Helen Legakis and Sandra Carriero
Ch. 9. Oligonucleotide assay and potency / Dennis P. Michaud -- ch. 10. Microbial analysis : endotoxin testing / Barbara J. Markley -- ch. 11. Analysis of residual solvents by head space gas chromatography / Sky Countryman and Jose V. Bonilla -- ch. 12. Determination of extinction coefficient / Veeravagu Murugaiah -- ch. 13. Structural determination by NMR / Michele L. DeRider, Doug Brooks, and Gary Burt -- ch. 14. Infrared analysis of oligonucleotides / Jose V. Bonilla -- ch. 15. Stability indicating methods for oligonucleotide products / Veeravagu Murugaiah -- ch. 16. Analysis by hydrophilic interaction chromatography / Renee N. Easter and Patrick A. Limbach -- ch. 17. Determination of base composition / Hüseyin Aygün -- ch. 18. Analysis of metals in oligonucleotides / Michael P. Murphy -- ch. 19. Regulatory considerations for the development of oligonucleotide therapeutics / G. Susan Srivatsa
Summary Handbook of Analysis of Oligonucleotides and Related Products
Bibliography Includes bibliographical references and index
Subject Oligonucleotides -- analysis.
Oligonucleotides -- Analysis
Oligonucleotides -- Analysis.
SCIENCE -- Life Sciences -- Molecular Biology.
Form Electronic book
Author Bonilla, Jose V. Editor.
Srivatsa, G. Susan. Editor.
LC no. 2010033563
ISBN 0429136668