UVB and UVA induced formation of photoproducts within cellular DNA -- Chemical sequencing profiles of photosensitized DNA damage -- DNA damage induced by UVA radiation : role in solar mutagenesis -- Mutations induced by UV and sunlight -- Mechanisms and mutagenic consequences of photoproduct bypass by replicative and DNA damage bypass polymerases -- The Ogg1 protein of Saccharomyces cerevisiae: properties and biological functions -- The role of a yeast homologue of the human phosphatase activator hPTPA in the cellular response to oxidative DNA damage -- DNA repair in RNA polymerase I transcribed genes -- Global genome nucleotide excision repair: key players and their functions -- Efficient repair of UV-induced DNA damage in terminally differentiated human keratinocytes -- Reactivation of UV-damaged viruses and reporter genes in mammalian cells -- Transcription of p53-regulated genes under transcriptional stress : implications for nucleotide excision repair -- What a difference a wavelength makes : the role of p53 in nucleotide excision repair of UV-induced DNA damage -- p53 and p33ING1 : Role in nucleotide excision repair of UV-damaged DNA -- Nuclear and non-nuclear signals leading to UV-induced apoptosis -- Opposing roles of UV-induced apoptosis in early skin cancer -- Acquired activation of signalling pathways in skin tumours from DNA repair-deficient xeroderma pigmentosum patients -- Chaos theory and self-organized criticality describe the DNA damage signal transduction network
Summary
As modern day society takes an increasing interest in outdoor activities, its exposure to sunlight has never been greater. As a consequence, countries throughout the world are experiencing a dramatic increase in the incidences of skin carcinomas and melanomas. From DNA photolesions to mutations, skin cancer and cell death provides an authoritative source of information for photobiologists interested in the series of genetic events that occur in the skin, and eventually lead to cancer. With contributions from eminent scientists in the field, this book includes the latest information on DNA photolesions and repair, as well as the key mechanisms of solar UV in skin cancer initiation and development. Significant information relating to UV-induced photolesions and mechanisms of skin tumour occurrence is also included. By providing the basic phenomena underlying the science and an overview of the biological events that take place when cells are exposed to solar UV radiation, From DNA photolesions to mutations, skin cancer and cell death is suitable to all researchers interested in the process of photocarcinogenesis
