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Title A handbook for DNA-encoded chemistry : theory and applications for exploring chemical space and drug discovery / edited by Robert A. Goodnow, Jr
Published Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
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Description 1 online resource
Contents Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology
Summary This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combi
Bibliography Includes bibliographical references and index
Notes Description based on print version record and CIP data provided by publisher
Subject Combinatorial chemistry -- Technique.
DNA -- Synthesis.
Combinatorial Chemistry Techniques -- methods.
Drug Discovery -- methods.
Gene Library.
Small Molecule Libraries -- chemical synthesis.
Form Electronic book
Author Goodnow, Robert A., Jr., editor of compilation
LC no. 2013046115
ISBN 1118487680
1118832639 ( mobi)
1118832671 (epub)
1118832698 (pdf)
1118832736
9781118487686
9781118832639 ( mobi)
9781118832677 (epub)
9781118832691 (pdf)
9781118832738
(cloth)