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E-book

Title Biomaterials for 3D tumor modeling / edited by Subhas C. Kundu and Rui L. Reis
Published Amsterdam, Netherlands : Elsevier, 2020
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Description 1 online resource
Series Materials today
Contents Front Cover -- Biomaterials for 3D Tumor Modeling -- Copyright Page -- Contents -- List of Contributors -- Preface -- I. Engineering biomaterials for 3D cancer modelling -- 1 Trends in biomaterials for three-dimensional cancer modeling -- Abbreviations -- 1.1 A historical introduction -- 1.1.1 In vitro and in vivo models: an overview -- 1.1.2 A paradigm shift -- 1.1.3 Three-dimensional biomaterials for cancer modeling -- 1.1.4 From the lab to the clinic -- 1.2 The three-dimensional tumor microenvironment -- 1.2.1 The tumor and its three-dimensional environment: a synergistic interaction
1.2.2 Biomaterials as a model of the tumor niche -- 1.2.2.1 Scaffold-based biomaterials -- 1.2.2.2 Matrix-based -- 1.2.2.3 Microcarrier-based -- 1.2.2.4 Scaffold-free: tumor spheroids -- 1.2.2.5 Microstructured surfaces -- 1.3 Engineering the native tumor microenvironment using custom-designed three-dimensional biomaterials -- 1.3.1 Tissue engineering approaches -- 1.3.1.1 Freeze-drying -- 1.3.1.2 Photopolymerization -- 1.3.1.3 Three-dimensional bioprinting -- 1.3.2 Nanotechnology approaches -- 1.3.2.1 Molding -- 1.3.2.2 Printing -- 1.3.2.2.1 (Two-dimensional) microcontact printing
1.3.2.2.2 Three-dimensional printing -- 1.3.2.2.3 Four-dimensional printing -- 1.4 Advanced models of the three-dimensional tumor microenvironment -- 1.4.1 Microfluidics-based models -- 1.4.1.1 Microfluidic-based models of tumors: tumor-on-a-chip -- 1.4.1.2 Drug discovery and screening on-chip -- 1.4.1.3 Reproducing dynamic events on-chip -- 1.4.1.4 Personalized tumor-on-a-chip models -- 1.4.1.5 Manufacturing methods of a tumor-on-a-chip -- 1.4.2 Three-dimensional bioprinted models -- 1.5 Applications of three-dimensional tumor models in cancer therapeutics
1.5.1 Drug discovery, development, and screening -- 1.5.2 Transport and delivery of drugs -- 1.6 Limitations of biomaterials-based three-dimensional tumor models -- 1.7 Future of three-dimensional biomaterials for cancer research -- 1.8 Final remarks and conclusions -- References -- 2 Bioinspired biomaterials to develop cell-rich spherical microtissues for 3D in vitro tumor modeling -- 2.1 Introduction -- 2.2 Human Tumor microenvironment-key hallmarks to mimic in vitro -- 2.3 3D In vitro tumor models-bridging the gap from 2D flat cultures to in vivo -- 2.4 Classes of 3D multicellular tumor models
2.4.1 Scaffold-free cell-rich 3D multicellular tumor spheroids -- 2.4.2 Scaffold-based 3D multicellular tumor models -- 2.4.2.1 Biomaterials for establishing physiomimetic 3D tumor microenvironments -- 2.4.2.1.1 Natural and nature-derived biomaterials for 3D tumor modeling -- Protein-based biomaterials -- Polysaccharide-based biomaterials -- 2.4.2.1.2 Synthetic biomaterials for 3D tumor modeling -- 2.4.2.1.3 Hybrid biomaterials for 3D tumor modeling -- 2.4.3 Generation of spherically structured cell-rich 3D tumor models -- 2.4.3.1 Microparticles for spherically structured 3D tumor models assembly
Notes Includes index
Subject Biomedical materials.
Three-dimensional imaging in medicine.
Tumors -- Computer simulation
Biomedical materials
Three-dimensional imaging in medicine
Form Electronic book
Author Kundu, S. C. (Subhas Chandra)
Reis, Rui L.
ISBN 012818129X
9780128181294