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Book Cover
Author Boelsterli, Urs A., 1948-

Title Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets / Urs A. Boelsterli
Edition Second edition
Published Boca Raton : CRC Press, 2007


Location Call no. Vol. Availability
Description 399 pages : illustrations ; 25 cm
Contents Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology
Summary "Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition examines xenobiotic-induced toxicity with regard to the molecular pathways that underlie toxic effects. This book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms at different toxicokinetic and toxicodynamic levels. The book includes extensive illustrations, references, and review articles at the end of each chapter, as well as boxed text for relevant review information. Linking molecular pathways to more general biomedical contexts, the author ensures the reader receives a broad understanding of the processes underlying xenobiotic toxicity."--BOOK JACKET
Bibliography Includes bibliographical references and index
Subject Molecular toxicology.
Toxicology -- methods.
Molecular Biology -- methods.
Signal Transduction.
Xenobiotics -- pharmacokinetics.
Xenobiotics -- toxicity.
LC no. 2006035219
ISBN 9780849372728