| Description |
1 online resource |
| Contents |
Cover; Title page; Copyright page; Contents; Contributors; About the Editors; Preface; Section A -- Engineered nanomaterials: hazard, exposure, risk assessment; Chapter 1 -- Bio-Nano Interactions; Introduction; Protein Corona on Nanoparticles; Development of the Protein Corona; Hard Corona Versus Soft Corona; The Biomolecule Corona Composition; Dynamic Formation of the Biocorona; Impact of the NP-Biomolecule Corona on Human Systems; In Vitro Studies; In Vivo Studies; Microbiome Interactions; Nanotoxicity and the Biomolecule Corona; Conclusions; Take-Home Messages; Acknowledgments; References |
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Chapter 2 -- Physicochemical CharacterizationIntroduction; Overview of Key Physicochemical Parameters; Modalities of Physicochemical Characterization; Particle Size, Size Distribution, Agglomeration, and Aggregation; Shape; Specific Surface Area and Porosity; Chemical Composition, Purity, and Crystal Structure (Crystallinity); Surface Chemistry (and Contamination); Surface Charge Density and Stability in Dispersion; Dispersibility and Solubility; Dustiness; Sample Preparation and Dispersion Media; Data Collection and Interpretation; Take-Home Messages; Acknowledgments; Disclaimer; References |
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Chapter 3 -- Toxicity Tests: In Vitro and In VivoIntroduction; Methods for Visualizing Cellular Uptake and Biodistribution; Evaluation of Transport and Uptake of ENM In Vitro and In Vivo; In Vitro Toxicity Tests; Cytotoxicity Tests; Limitations of In Vitro Tests; New In Vitro Test Principles; Validated Cytotoxicity Tests; Genotoxicity Tests; Ex Vivo Models; In Vivo Toxicity Testing; Toxicokinetics; Immunological Responses; Chronic Toxicity and Carcinogenicity; Considerations for Selection of Toxicity Tests: In Vitro/In Vivo Comparison; Conclusions; Take-Home Messages; Acknowledgments |
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How can Workers be Exposed to ENMs?Exposure Routes; Characterization of Behavior of ENMs; Challenges to Assess Exposure to ENMs; Exposure Assessment of ENMs in Workplaces; Evidence for Release of Engineered Nanoparticles in the Workplace; Harmful Effects on Workers; How to Measure Nanoparticles: Metrics; How to Measure Nanoparticles: Measurement Strategies; Instruments Measuring Number Concentration; Instruments Measuring Surface Concentration; Instruments Measuring Mass Concentration; Instruments Giving Indirect Estimates; Sample Collection and Characterization |
| Summary |
Bio-nano interactions / Dana Westmeier, Shirley K. Knauer, Roland H. Stauber, Dominic Docter -- Physicochemical characterization / Kristen Rasmussen, Hubert Rauscher, Agnieszka Mech -- Toxicity tests / Maria Dusinska, Elise Rundén-Pran, Jürgen Schnekenburger, Jun Kanno -- Computational approaches / Tu C. Le, Vidana Epa, Lang Tran, Dave Winkler -- Exposure Assessment / Kai Savolainen, Antonio Pietroiusti -- Biomonitoring / Enrico Bergamaschi, Irirna Guseva Canu, Adriele Prina-Mello, Regulation and legislation / Kirsten Rasmussen, Brigit Sokull-Klüttgen, IL Je Yu, Jun Kanno, Akihiro Hirose, Maureen R. Gwinn -- Risk assessment and risk management / Robert Landsiedel, Ursula G. Sauer, Wim H De Jong -- Respiratory system, part one / Craig A. Plooand, Ken Donaldson -- Respiratory system, part two / Harri Alenius, Michael R. Shurin, Galina V. Shurin, Don Beezhold, Anna A. Shvedova -- Cardiovascular system / Jennifer B. Raftis, Nicholas L. Mills, Rodger Duffin -- Neurological system / Myrtill Simkó, Mats-olof Mattsson, Robert A. Yokel -- Immune system / Diana Boraschi, Bengt Fadeel, Albert Duschl -- Endorine system / Xuefei Lu, Yong Zhu, Tao Zhu -- Skin / Nancy A. Monteiro-Riviere, Francesca Larese Filon -- Gastrointestinal system / Mark A. Jepson, Hans Bouwmeester -- Reproduction and development / Luisa Campagnolo, Karin S. Hougard -- Genotoxicitiy and cancer / Shareen H. Doak, Ying Liu, Chunying Chen |
| Bibliography |
Includes bibliographical references and index |
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ReferencesChapter 4-Computational Approaches; Introduction; Challenges in Modeling Nanoparticle Biological Effects; Examples of Nanotoxicology Modeling Approaches; Quantum Chemical Studies of Toxicity of Nanoparticles; Statistical Modeling and Machine Learning Methods; Nanotoxicological Fingerprints to Classify Nanomaterials; Molecular Modeling and Molecular Dynamics Methods; Elucidating Interactions Between Nanomaterials and Proteins; Other Modeling Approaches for Nanotoxicology; Conclusions; Take-Home Messages; References; Chapter 5-Exposure Assessment; Background |
| Notes |
ENM Modifications After Their Release |
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Print version record |
| Subject |
Nanostructured materials -- Toxicology
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Risk assessment.
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Nanostructures -- adverse effects
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Nanostructures -- toxicity
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Environmental Exposure -- adverse effects
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Risk Assessment
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risk assessment.
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MEDICAL -- Pharmacology.
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Risk assessment
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| Genre/Form |
Electronic books
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| Form |
Electronic book
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| Author |
Fadeel, Bengt, editor.
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Pietroiusti, Antonio, editor.
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Shvedova, Anna A., editor.
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| LC no. |
2016960838 |
| ISBN |
9780128094907 |
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0128094907 |
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0128091991 |
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9780128091999 |
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