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Title Transcranial direct current stimulation in neuropsychiatric disorders : clinical principles and management / André Brunoni, Michael Nitsche, Colleen Loo, editors
Published Cham : Springer, 2016
Online access available from:
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Description 1 online resource (421 pages)
Contents Foreword; References ; Preface; Contents; Contributors; Part I: Introduction and Mechanisms of Action; 1: Historical Aspects of Transcranial Electric Stimulation; The First Clinical-Therapeutic Electrical Applications: The Electric Fish; Transcranial Electrical Stimulation: From Electrostatic Machines to Volta's Pile; The Reappraisal of Transcranial Direct Current Stimulation (tDCS) from 1960 Onward; Concluding Remarks; References; 2: The New Modalities of Transcranial Electric Stimulation: tACS, tRNS, and Other Approaches; Introduction; tACS: Intrusion with Brain Oscillation
Modulating the Activity of the Human Brain Using tACS Using tACS on Another Way: tRNS; Other Types of Oscillatory tES: Oscillating Transcranial Direct Current Stimulation (o-DCS); Clinical Applications; Conclusions; References; 3: Physiology of Transcranial Direct and Alternating Current Stimulation; Introduction; tDCS; tDCS Protocols and Effects; Current Intensity/Density; Electrode Position/Configuration/Current Direction; Stimulation Duration/Interval; tDCS Physiology; Regional Effects of tDCS; Acute Change of Cortical Excitability
Sustained Change of Cortical Excitability and ActivityPharmacology of tDCS; tDCS Effect on Cortical Regions Other Than M1; Inter-regional Effects of tDCS; tACS; tACS Protocols and Effects; Physiological Effects of tACS; tACS Effects on Cognition and Behaviour; General Remarks; References; 4: Computer-Based Models of tDCS and tACS; Overview of Computational Models of Noninvasive Neuromodulation; Methods and Protocols in the Generation of Computational Forward Models of tDCS/tACS; Pitfalls and Challenges in the Application and Interpretation of Computational Model Predictions
Use of Computational Models in Clinical Practice: Consideration for EfficacyUse of Computational Models in Clinical Practice: Consideration for Safety; Use of Computational Models in Clinical Practice: Consideration for Individual Dose Titration; Example Results of Computational Analysis in Susceptible Populations; Conclusion; References; 5: Animal Studies in the Field of Transcranial Electric Stimulation; Experimental Design of tDCS and tACS Animal Studies; Classification of Animal Studies and Relevance to Clinical Protocols; tDCS and tACS Dose; The Quasi-Uniform Assumption
Translation from Animal Studies to Clinical Applications: The Importance of IntensitySafety Concerns; Relating Biomarkers from Animal Models to Humans; Neuronal Polarization; Polarity-Specific Effects for DCS and Implications for ACS; Quantifying Neuronal Polarization with Coupling Constants; Synaptic Plasticity; Network Effects; tDCS and Oscillations; tACS and Oscillations; Applications to Clinical Pathologies; Addiction; Alzheimer's Disease; Chronic Stress; Prospects for Animal Research in tDCS/tACS Informing Ongoing Human Trials; References
Summary The aim of this book is to provide a comprehensive review of the use of Transcranial Direct Current Stimulation (tDCS) in different psychiatric conditions. Here we review tDCS clinical studies employing different types of design (from single-session tDCS studies to randomized clinical trials) as well as studies evaluating the impact of tDCS in neurophysiological, behavioral and brain imaging outcomes. Although the understanding about physiological foundations and effectiveness of clinical therapies of psychiatric diseases has been considerably increased during the last decades, our knowledge is still limited, and consequently psychiatric diseases are still a major burden to the individual patient and society. Recently, interest in pathological alterations of neuroplasticity in psychiatric diseases as a critical condition for development, and amelioration of clinical symptoms increased, caused by the fact that new tools, such as functional imaging, and brain stimulation techniques do allow to monitor, and modulate these phenomena in humans. Especially non-invasive brain stimulation techniques evolved as an attractive potential new therapeutic tool. The interest in non-invasive brain stimulation has grown exponentially in the past 25 years, with the development of non-pharmacological, neuromodulatory techniques such as tDCS and repetitive transcranial magnetic stimulation (rTMS). TDCS, although even newer than rTMS, has attracted considerable attention in both basic and clinical research scenarios. In the context of clinical research, tDCS is being increasingly investigated as a novel treatment tool for several psychiatric disorders, such as major depression, schizophrenia and neurocognitive and substance abuse disorders. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders - Clinical Principles and Management intends to serve as a practical guide on the field, attracting the interest of psychiatrists, neurologists and neuroscientists with little or no experience with tDCS, as well as those with a background on tDCS who want to increase their knowledge in any particular psychiatric condition
Notes 6: Cortical Inhibition and Excitation in Neuropsychiatric Disorders Using Transcranial Magnetic Stimulation
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Magnetic brain stimulation.
Mental Disorders -- therapy.
Transcranial Direct Current Stimulation -- methods.
Form Electronic book
Author Brunoni, André.
Nitsche, Michael.
Loo, Colleen.
ISBN 9783319339672 (electronic bk.)
3319339672 (electronic bk.)