| Description |
1 online resource (1 volume) : illustrations (some color) |
| Series |
Methods in molecular medicine ; 75 |
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Methods in molecular medicine ; 75.
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| Contents |
Molecular and genetic aspects of lung cancer / W.N. Rom and K.M. Tchou-Wong-Molecular alterations in lung cancer. Impact on prognosis / T. Kijima, G. Maulik and R. Salgia-Cellular predictive factors of drug resistance in non-small cell lung carcinomas / M. Volm, R. Koomagi and W. Rittgen-Clinical implications of p53 mutations in lung cancer / B.G. Campling and W.S. el-Deiry-An epidemiologic and clinicopathologic overview of aids-associated pulmonary kaposi's sarcoma / D.M. Aboulafia-Myeloperoxidase promoter region polymorphism and lung cancer risk / X. Wu, M.B. Schabath and M.R. Spitz-Clinical utility of tumor markers in the management of non-small cell lung cancer / D.E. Niewoehner and J.B. Rubins-Detection of chromosomal aberrations in lung tissue and peripheral blood lymphocytes using interphase fluorescence in situ hybridization (fish) / R.A. el-Zein and S.Z. Abdel-Rahman-In situ analysis of telomerase rna gene expression as a marker for tumor progression / W.N. Keith-A high-throughput methodology for identifying molecular targets overexpressed in lung cancers / T. Wang and S.G. Reed-Expression profiling of lung cancer based on suppression subtraction hybridization (ssh) / S. Petersen and I. Petersen-Comparative genomic hybridization of human lung cancer / I. Petersen-Sensitive assays for detection of lung cancer. Molecular markers in blood samples / M.V. Fournier [and others]-Fluorescent microsatellite analysis in bronchial lavage as a potential diagnostic tool for lung cancer / J.K. Field and T. Liloglou-Southern blotting of genomic DNA from lung and its tumors. Application to analysis of allele loss on chromosome 11p15.5 / D.M. Pitterle and G. Bepler-Assessment of insulin-like growth factors and mutagen sensitivity as predictors of lung cancer risk / X. Wu [and others]-Comparative multiplex pcr and allele-specific expression analysis in human lung cancer. Tools to facilitate target identification / J. Heighway [and others]-Detection of k-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-exacct / V.A. Somers and F.B. Thunnissen-Detection of k-ras and p53 mutations by "mutant-enriched" pcr-rflp / M. Schuermann-Detection of small cell lung cancer by rt-pcr for neuropeptides, neuropeptide receptors, or a splice variant of the neuron restrictive silencer factor / J.M. Coulson [and others]-Utilization of thyroid transcription factor-1 immunostaining in the diagnosis of lung tumors / N.G. Ordonez-Molecular biologic substaging of stage i nsclc through immunohistochemistry performed on formalin-fixed, paraffin-embedded tissue / M.B. Joshi, T.A. D'Amico and D.H. Harpole, Jr.-A sensitive immunofluorescence assay for detection of p53 protein in the sputum / Z. Feng, D. Tian and R. Goldman-Spr1. An early molecular marker for bronchial carcinogenesis / D. Lau [and others]-Determination of biological parameters on fine-needle aspirates from non-small cell lung cancer / C. Bozzetti [and others]-Detection and analysis of lung cancer cells from body fluids using a rare event imaging system / S.K. Kraeft, R. Salgia and L.B. Chen-Reconstruction of geno-phenotypic evolutionary sequences from intracellular patterns of molecular abnormalities in human solid tumors / S.E. Shackney [and others]-Surgical treatment of lung cancer. Past and present / C.F. Mountain and K.E. Hermes-Recent advances and dilemmas in the radiotherapeutic management of locally advanced non-small cell lung cancer / B. Movsas-Photodynamic therapy in lung cancer. A review / D. Ost-Gene therapy for lung cancer. An introduction / E.B. Haura, E. Sotomayor and S.J. Antonia-Identifying obstacles to viral gene therapy for lung cancer. Malignant pleural effusions as a paradigm / R.K. Batra, R.M. Bernal and S. Sharma-Topical gene therapy for pulmonary diseases with pei-DNA aerosol complexes / A. Gautam [and others]-Targeted delivery of expression plasmids to the lung via macroaggregated polyethylenimine-albumin conjugates / F.M. Orson [and others]-Preparation of retroviral vectors for cell-cycle-targeted gene therapy of lung cancer / P.P. Claudio and A. Giordano-Aerosol gene therapy for metastatic lung cancer using pei-p53 complexes / A. Gautam [and others]-Clinical development of antisense oligonucleotides as anti-cancer therapeutics / H.X. Chen-Antisense oligonucleotides targeting ri alpha subunit of protein kinase a. In vitro and in vivo anti-tumor activity and pharmacokinetics / R. Zhang and H. Wang-Use of antisense oligonucleotides for therapy. Manipulation of apoptosis inhibitors for destruction of lung cancer cells / S.H. Leech, R.A. Olie and U. Zangemeister-Wittke-Induction of programmed cell death with an antisense bcl-2 oligonucleotide / P.P. Koty, W. Lei and M.L. Levitt-Tumor vaccination with cytokine-encapsulated microspheres / N.K. Egilmez [and others]-Adoptive immunotherapy / J.A. Kim and S. Shu-Intratumoral therapy with cytokine gene-modified dendritic cells in murine lung cancer models / S. Sharma [and others]-Cyclooxygenase 2-dependent regulation of antitumor immunity in lung cancer / S. Sharma [and others]-Chemoprevention of lung cancer / H. Witschi-Assessing the interaction of particulate delivery systems with lung surfactant / T.S. Wiedmann-Chemopreventive therapeutics. Inhalation therapies for lung cancer and bronchial premalignancy / M. Haigentz, Jr. and R. Perez-Soler |
| Summary |
Molecular-based laboratory methods can help significantly in the diagnosis and treatment of lung cancer, a leading cause of death worldwide. In Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, leading physicians, scientists, and noted researchers describe step-by-step techniques for lung cancer diagnosis based on the molecular analysis of clinical samples. These experts review currently accepted treatments and outline a variety of novel therapies, including treatments based on gene therapy, immunotherapy, and chemoprevention, and show how these newly improved techniques can give a better appreciation of the prognosis associated with the particular mutation uncovered by the technique. These methods use a variety of molecular techniques, including the manipulation of gene expression and the alteration of immune status, to combat lung cancer. A companion volume, Lung Cancer, Volume 1: Molecular Pathology Methods and Reviews, illuminates the etiology of lung cancer and provides reliable techniques for detecting the responsible genetic mutations at the cellular, DNA, and protein levels. Comprehensive and informative, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews illuminates how molecular approaches can and are being applied to the diagnosis of lung cancer. Together, these two volumes constitute an unprecedented resource for those who wish to better understand how this disease is being diagnosed and treated, and what novel techniques may be available to improve both processes |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer Protocols |
| Subject |
Lungs -- Cancer -- Molecular aspects -- Laboratory manuals
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Lungs -- Cancer -- Gene therapy -- Laboratory manuals
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Molecular diagnosis -- Laboratory manuals
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Tumor markers -- Laboratory manuals
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Lung Neoplasms -- physiopathology
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Lung Neoplasms -- diagnosis
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Lung Neoplasms -- therapy
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Molecular Biology -- methods
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Lungs -- Cancer -- Gene therapy
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Lungs -- Cancer -- Molecular aspects
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Molecular diagnosis
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Tumor markers
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Longkanker.
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Wetenschappelijke technieken.
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| Genre/Form |
Laboratory manuals
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Laboratory manuals.
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Manuels de laboratoire.
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| Form |
Electronic book
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| Author |
Driscoll, Barbara.
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| ISBN |
9781592593248 |
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1592593240 |
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9780896039209 |
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089603920X |
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