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E-book

Title Cancer genome and tumor microenvironment / Andrei Thomas-Tikhonenko, editor
Published New York : Springer, 2010

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Description 1 online resource (xi, 497 pages) : illustrations (some color)
Series Cancer Genetics
Cancer genetics.
Contents Opening Remarks -- Hardwiring Tumor Progression -- Breaking Away: Epithelial-Mesenchymal Transition -- PI3K/AKT Pathway and the Epithelial-Mesenchymal Transition -- Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells -- Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironment -- Merlin/NF2 Tumor Suppressor and Ezrin-Radixin-Moesin (ERM) Proteins in Cancer Development and Progression -- Coming up for Air: Hypoxia and Angiogenesis -- von Hippel-Lindau Tumor Suppressor, Hypoxia-Inducible Factor-1, and Tumor Vascularization -- RAS Oncogenes and Tumor-Vascular Interface -- Myc and Control of Tumor Neovascularization -- p53 and Angiogenesis -- Ink4a Locus: Beyond Cell Cycle -- Gaining New Ground: Metastasis and Stromal Cell Interactions -- Nm23 as a Metastasis Inhibitor -- HGF/c-MET Signaling in Advanced Cancers -- Contribution of ADAMs and ADAMTSs to Tumor Expansion and Metastasis -- Stromal Cells and Tumor Milieu: PDGF et al. -- TGF-? Signaling Alterations in Neoplastic and Stromal Cells -- Getting Attention: Immune Recognition and Inflammation -- Genetic Instability and Chronic Inflammation in Gastrointestinal Cancers -- Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesis -- Modulation of Philadelphia Chromosome-Positive Hematological Malignancies by the Bone Marrow Microenvironment -- Putting It All Together -- Melanoma: Mutations in Multiple Pathways at the Tumor-Stroma Interface -- Cooperation and Cancer
Summary Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. The commonly held view is that changes in tumor microenvironment are 'soft-wired', that is, epigenetic in nature and often reversible
Analysis neoplasms
oncologie
oncology
biomedische wetenschappen
biomedicine
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer eBooks
Subject Tumors -- Immunology -- Genetic aspects
Genomics.
Cancer -- Genetic aspects.
Tumors -- Immunological aspects -- Genetic aspects
Neoplasms -- immunology
Genomics
Neoplasms -- etiology
Neoplasms -- genetics
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Tumors -- Immunology -- Genetic aspects.
Genomics.
Cancer -- Genetic aspects.
Biomédecine.
Sciences de la vie.
Cancer -- Genetic aspects
Genomics
Form Electronic book
Author Thomas-Tikhonenko, Andrei
LC no. 2009934786
ISBN 9781441907110
1441907114