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Title Non-neuronal mechanisms of brain damage and repair after stroke / Jun Chen, John H. Zhang, Xiaoming Hu, editors
Published Switzerland : Springer, 2016
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Description 1 online resource (xiii, 408 pages) : illustrations
Series Springer series in translational stroke research
Springer series in translational stroke research.
Contents Introduction: Nonneuronal Mechanisms and Targets for Stroke; Contents; Contributors; Part I: Microvascular Integrity in Stroke; Structural Alterations to the Endothelial Tight Junction Complex During Stroke; 1 Introduction; 2 Normal BBB Structure and Function.; 3 Alterations in BBB Function After Stroke; 4 Alterations to TJ Structure After Stroke; 5 Signaling Mechanisms Underlying Alterations in TJ Structure in Stroke; 6 Non-TJ Pathways Involved in BBB Hyperpermeability After Stroke; 7 Therapeutic Interventions; 8 Conclusions; References; Role of Pericytes in Neurovascular Unit and Stroke
1 Neurovascular Unit and Stroke2 Pericytes; 2.1 Regulation of Microcirculatory Blood Flow and BBB by Pericytes; 2.2 Pericytes Are Vulnerable to Ischemic Injury; 3 Changes in Pial and Penetrating Arteries Shortly After Stroke; 4 Incomplete Microcirculatory Reflow After Recanalization; 5 Clinical Evidence for "No-Reflow" After Recanalization Therapies for Stroke; 6 Role of Pericytes in CADASIL; 7 Post-stroke Angioneurogenesis and Pericytes; References; Glial Support of Blood-Brain Barrier Integrity: Molecular Targets for Novel Therapeutic Strategies in Stroke; 1 Introduction
2 The Neurovascular Unit2.1 Components of the Neurovascular Unit; 2.1.1 Endothelial Cells and the Blood-Brain Barrier; 2.2 Molecular Characteristics of the BBB; 2.2.1 Tight Junction Protein Complexes; 2.2.2 Adherens Junctions; 2.3 Transporters; 2.4 Astrocytes; 2.5 Microglia; 2.6 Pericytes; 2.7 Neurons; 2.8 Extracellular Matrix; 3 Ischemic Stroke; 3.1 Overview of Ischemic Stroke; 3.2 The Neurovascular Unit in Ischemic Stroke; 3.2.1 Disruption of the Blood-Brain Barrier; 3.3 Ischemic Stroke and Glial Support of the BBB; 3.4 Targeting the Neurovascular Unit in Ischemic Stroke
3.4.1 Targeting the Tight Junction3.5 Targeting Endogenous BBB Transporters; 3.6 Targeting Glial Support of the BBB; 4 Conclusion; References; Barrier Mechanisms in Neonatal Stroke; 1 Introduction; 2 Development of the BBB and Other Brain Barriers; 3 Blood-Brain Barrier and Adult Stroke; 4 Maturation-Dependent Susceptibility of the BBB to Inflammation; 5 Models of Neonatal Focal Stroke and Hypoxia-Ischemia; 6 BBB Integrity After Neonatal Focal Stroke and Hypoxia-Ischemia; 7 Leukocyte and BBB Integrity After Neonatal Stroke; 8 BBB Integrity, Angiogenesis and Brain Repair After Neonatal Stroke
9 Conclusions and Future DirectionsReferences; Angiogenesis: A Realistic Therapy for Ischemic Stroke; 1 Introduction; 2 Overview of Angiogenesis; 3 Angiogenesis After Ischemic Stroke; 4 Regulation of Angiogenesis After Ischemic Stroke; 5 Functional Roles of Angiogenesis in Stroke Long-Term Remodeling and Functional Recovery; 6 Therapeutic Angiogenesis in Ischemic Stroke; References; Part II: Glial Cells in Stroke; Astrocytes as a Target for Ischemic Stroke; 1 A Brief Overview of Astrocytes; 2 Astrocytes in Ischemic Stroke; 2.1 Astrocyte and Glutamate Uptake in Ischemic Stroke
Summary This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials
Notes Online resource; title from PDF title page (SpringerLink, viewed August 23, 2016)
Subject Cerebrovascular disease -- Molecular aspects.
Brain damage -- Molecular aspects.
Stroke -- therapy.
Neovascularization, Physiologic.
Neuroglia.
Stroke -- immunology.
White Matter.
Form Electronic book
Author Chen, Jun (Professor of neurology and pharmacology), editor
Zhang, J. H. (John H.), editor
Hu, Xiaoming, editor
ISBN 9783319323374 (electronic bk.)
3319323377 (electronic bk.)
(print)