| Description |
1 online resource (x, 432 pages) : illustrations |
| Contents |
Front cover; Contents; Contributors; Editors; Preface; INTRODUCTION; Chapter 1; Penetration Enhancer Classification; CONTENTS; Introduction; Drug Transport Routes through Human Skin; Enhancing Transdermal Drug Delivery; References; Chapter 2; Structure-Activity Relationship of Chemical Penetration Enhancers; CONTENTS; Introduction; Fatty Acids; Fatty Alcohols; Terpenes; Pyrrolidones; Surfactants; Conclusions; References; Chapter 3; Quantitative Structure- Enhancement Relationship and the Microenvironment of the Enhancer Site of Action; CONTENTS; Introduction; Methods |
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Quantitative Structure-Enhancement Relationships Based on Aqueous Concentrations of the EnhancerQuantitative Structure-Enhancement Relationship Based on Enhancer Concentrations in the Stratum Corneum Intercellular Lipids; Microenvironment of the Site of Enhancer Action; Transdermal Drug Delivery; Acknowledgment; References; Chapter 4; The Role of Prodrugs in Penetration Enhancement; CONTENTS; Push versus Pull Mechanisms for Penetration Enhancers; Basis for Prodrugs as Penetration Enhancers; Acyl versus Soft Alkyl Promoieties; Mechanisms for Penetration Enhancement |
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Table 4.1 Prodrugs of 5-FluorouracilTable 4.2 Prodrugs of Levonorgestrel; Table 4.3 Prodrugs of Indomethacin and Naproxen; Table 4.4 Prodrugs of Naproxen, Ketoprofen, and Diclofenac; Conclusion; References; VEHICLE EFFECTS IN PENETRATION ENHANCEMENT; Chapter 5; Penetration Enhancement by Skin Hydration; CONTENTS; Introduction; Stratum Corneum Hydration by Occlusion; Stratum Corneum Hydration by Exogenous Chemicals; Conclusions; References; Chapter 6; Enhancement of Delivery with Transdermal Sprays; CONTENTS; Introduction; Enhancement of Delivery of the Dose to the Skin |
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Enhancement of Delivery into the Stratum CorneumEnhancement of Permeation through Skin; Enhancement of Bioavailability; Characteristics of Solvents and Enhancers Required for Metered Dose Spray Delivery; References; Chapter 7; Hydrogel Vehicles for Hydrophilic Compounds; CONTENTS; Hydrogels; Applications of Hydrogels and Patches in Transdermal Delivery; Conclusions; References; Chapter 8; Enhanced Skin Permeation Using Ethosomes; CONTENTS; Introduction; Definition, Structure, and the Main Properties of Ethosomes; Mechanism of Skin Permeation Enhancement by Means of Ethosomes |
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Various Aspects of Ethosomal Delivery SystemSummary; Acknowledgment; References; Chapter 9; Microemulsions in Topical Drug Delivery; CONTENTS; Introduction; Microemulsions in Topical Drug Delivery; Conclusions; References; Chapter 10; Nanoparticles as Carriers for Enhanced Skin Penetration; CONTENTS; Introduction; Microparticles for Enhancing Skin Penetration; Nanoparticles for Enhancing Skin Penetration; PNBCA Nanocapsules as a Carrier for Enhanced Skin Penetration of Indomethacin |
| Summary |
INTRODUCTIONPenetration Enhancer Classification, B.W. Barry Structure-Activity Relationship of Chemical Penetration Enhancers, N. Kanikkannan, J.B. Ramapuram, and M. Singh Quantitative Structure-Enhancement Relationship and the Microenvironment of the Enhancer Site of Action, S.K. Li and W.I. Higuchi The Role of Prodrugs in Penetration Enhancement, K.B. Sloan and S.C. Wasdo VEHICLE EFFECTS IN PENETRATION ENHANCEMENT Penetration Enhancement by Skin Hydration, J. Zhang, C.H. Purdon, E.W. Smith, H.I. Maibach, and C. Surber Enhancement of Delivery with Transdermal Sprays, B.C. Finnin and J. Hadgra |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Transdermal medication.
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Skin absorption.
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Skin Absorption -- drug effects
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Skin Absorption
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Administration, Cutaneous
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MEDICAL -- Pharmacology.
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Skin absorption
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Transdermal medication
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| Form |
Electronic book
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| Author |
Smith, Eric W
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Maibach, Howard I
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| ISBN |
1420039202 |
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9781420039207 |
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