Book Cover
Author Millán, José Luis.

Title Mammalian alkaline phosphatases : from biology to applications in medicine and biotechnology
Published Weinheim : Wiley-VCH, [2006]
Online access available from:
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Description 1 online resource (xv, 322 pages)
Contents Preface -- Abbreviations -- Glossary -- Introduction -- pt. I. Gene and protein structure ; 1. Gene structures ; 2. Developmental expression ; 3. Gene regulation ; 4. Protein structure and functional domains ; 5. Enzymatic properties ; 6. Epitope maps -- pt. II. In vivo functions ; 7. The in vivo role of TNAP ; 8. Knockout mouse models -- pt. III. AP expression in health and disease ; 9. APs as physiological and disease markers ; 10. Neoplastic expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP isozymes -- pt. IV. Uses of APs in industry and biotechnology ; 11. Applications of recombinan APs ; 12. Use of APs in prodrug converting strategies ; 13. APs as therapeutic agents ; 14. APs in the food industry ; 15. Veterinary uses of AP determinations ; 16. Methodologies
Summary A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: The structure, regulation and expression of the AP genes; The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes; The phenotypic abnormalities of the different AP knockout mice; Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzym
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
Subject Alkaline Phosphatase -- genetics.
Alkaline Phosphatase -- therapeutic use.
Mammals -- genetics.
Models, Animal.
Models, Genetic.
Alkaline phosphatase.
Form Electronic book
Author John Wiley & Sons.
ISBN 3527310797 (print edition)
3527607471 (electronic bk.)
3527608060 (electronic bk.)
9783527310791 (print edition)
9783527607471 (electronic bk.)
9783527608065 (electronic bk.)