| Description |
1 online resource (281 pages) : illustrations |
| Series |
NUTRITIONnetBASE
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| Contents |
Front cover; Preface; About the Editors; Contributors; Table of Contents; Chapter 1; Nutrient and Gene Interactions in Cancer; 1.1 Introduction; 1.2 Types of Epidemiological Studies; 1.3 Ecological Studies; 1.4 Analytic Epidemiology: Case-Control and Prospective Cohort Studies; 1.5 Confounding; 1.6 Randomized Intervention Trials; 1.7 The Combined Study of Genetics and Nutrition in Epidemiological Studies; 1.8 Public Health Implications of Nutrient-Environment Interactions; 1.9 Summary and Conclusion; References; Chapter 2; Candidate Mechanisms for Interactions between Nutrients and Genes |
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2.1 Introduction2.2 Nutritional Modulation of Gene Expression; 2.2.1 Effects on Transcription; 2.2.1.1 Cis-Acting Elements; 2.2.1.2 Transcription Factors Are Trans-Acting Factors; 2.2.1.3 Epigenetic Modifications; 2.2.2 Posttranscriptional Control of Gene Expression; 2.2.3 Posttranslational Modification; 2.3 Impact of Genotype on Responses to Nutrients; 2.4 Mechanisms by which Food Constituents May Influence Carcinogenesis; 2.4.1 Nutrition, Inflammation, and Cancer Risk; 2.4.1.1 Intestinal Bacteria; 2.4.1.2 Obesity; 2.5 Nutritional Modulation of DNA Damage and Repair |
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2.6 Developmental Origins of Cancer2.7 Concluding Remarks; References; Chapter 3; Biomarkers for Nutrient-Gene Interactions; 3.1 Dietetic Modification of Cancer Risk and Relevant Biomarkers; 3.1.1 Fruit, Vegetables, and Decreased Cancer Risk: Putative Mechanisms; 3.1.1.1 Oxidative DNA Damage (8-OHdG); 3.1.1.2 Bulky DNA Adducts and Mutagen Sensitivity; 3.1.2 High Meat Consumption and Increased Risk of Colorectal Cancer; 3.1.2.1 Heterocyclic Aromatic Amines (HAA) and HAA Adducts; 3.1.2.2 N-Nitroso Compounds; 3.1.3 Single Nutrients: Folate |
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3.1.3.1 Evidence and Strength of Association from Cohort Studies3.1.3.2 Alcohol and Folate; 3.2 Genetic Susceptibility; 3.3 Combination of Genes and Pathways; 3.4 Fruit, Vegetables, and Decreased Cancer Risk; 3.4.1 Hypothesis I: Role of GSTs; 3.4.2 Hypothesis II: Repair of Oxidative DNA Damage; 3.5 High Meat Consumption and Increased Risk of Colorectal Cancers; 3.6 Folate; 3.6.1 Folate and MTHFR Polymorphisms; 3.6.2 Folate and Promoter Methylation; 3.7 Conclusion; Acknowledgments; Abbreviations; References; Chapter 4 |
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Interaction between Folate and Methylene- tetrahydrofolate Reductase Gene in Cancer4.1 Introduction; 4.2 Folate and the Risk of Colorectal Cancer; 4.3 Importance of Folate and MTHFR Gene in One-Carbon Metabolism; 4.4 Interaction between Folate and MTHFR Gene; 4.4.1 Characteristics of MTHFR Gene Polymorphisms; 4.4.2 Mechanism of Folate and MTHFR Gene Interaction; 4.4.3 Effect of Folate and MTHFR Gene Interaction on DNA Methylation; 4.5 Interaction between Folate and MTHFR Gene in Colorectal Carcinogenesis; 4.6 Interaction between Folate and MTHFR Gene in Other Neoplastic Diseases |
| Summary |
Nutrients and Gene Interactions in Cancer, E. GiovannucciCandidate Mechanisms for Interactions between Nutrients and Genes, J.C. MathersBiomarkers for Nutrient-Gene Interactions, C.E. Robertson and P. VineisInteraction between Folate and Methylene-tetrahydrofolate Reductase (MTHFR) Gene in Cancer, S. Friso and S.-W. ChoiGenetic Variability in Folate-Mediated One-Carbon Metabolism and Cancer Risk, C.M. UlrichS-Adenosylmethionine and Methionine Adenosyltransferase Genes, J.M. Mato, M.L. MartÃnez-Chantar, and S.C. LuEffects of Carotenoid Supplementation on Signal Transduction Pathways: Significan |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Cancer -- Nutritional aspects.
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Gene expression.
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Genetic regulation.
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Nutrition.
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Gene Expression Regulation
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Neoplasms -- genetics
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Epidemiologic Studies
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Genes -- physiology
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Nutritional Physiological Phenomena
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Gene Expression
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Nutrition
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Cancer -- Nutritional aspects
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Gene expression
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Genetic regulation
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| Form |
Electronic book
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| Author |
Choi, Sang-Woon
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Friso, Simonetta
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| ISBN |
1420004840 |
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9781420004847 |
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084933229X |
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9780849332296 |
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