Title Cholinergic mechanisms : function and dysfunction / edited by Israel Silman [and others]

Published London ; New York : Taylor & Francis, 2004

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Description 1 online resource (lxiv, 774 pages) : illustrations Contents Front Cover -- Cholinergic Mechanisms: Function and Dysfunction -- Copyright Page -- Contents -- Preface -- List of contributors -- Platform presentations -- Edith Heilbronn Lecture -- 1. In memoriam: Edith Heilbronn -- Nicotinic receptors: structure -- 2. Nicotinic acetylcholine receptors: probing functionally significant structural changes with site-directed reactions -- 3. The binding site for Î"-bungarotoxin in the acetylcholine receptor: from synthetic peptides to solution and crystal structure 4. Pharmacological and structural characterization of the interaction of snake toxins with nicotinic acetylcholine receptors5. Structure and dynamics of acetylcholine receptor and its lipid microenvironment: from molecule to cell -- 6. Site-directed reactive probes for structural and functional investigation of cholinergic proteins -- 7. The mechanism for acetylcholine receptor inhibition by Î"-neurotoxins and species-specific resistance to Î" -bungarotoxin revealed by NMR -- Muscarinic receptors: structure -- 8. Structure and activation of muscarinic acetylcholine receptors 9. Generation and analysis of muscarinic acetylcholine receptor knockout mice10. Roles of external loops of muscarinic receptors in interactions between N-methylscopolamine and allosteric modulators -- Couteaux lecture -- 11. Rene Couteaux (1909â€?1999) and his presynaptic active zone -- 12. René Couteaux Lecture: Ligand recognition in the cholinergic nervous system analysed by structural templates and protein dynamics -- Presynaptic mechanisms -- 13. Neuronal calcium dynamics: one message with many meanings 14. Acetylcholine- and glutamate-mediated transmission: one mediatophore with different specificities, or several mediatophores?15. The Ca-voltage hypothesis for neurotransmitter release â€? current status -- Structural and regulatory aspects of the cholinergic synapse -- 16. The role of P2Y1 nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junctions -- 17. Control of expression of nicotinic receptor and acetylcholinesterase in the developing neuromuscular junction in the human muscle 18. The molecular neurobiology of acetylcholinesterase variants: from stressful insults to antisense intervention19. Transcriptional control of the cholinergic gene locus: a mosaic model for regulation of the cholinergic phenotype -- 20. Regulation of cholinergic gene expression by NRSF/REST -- 21. Unveiling the molecular events leading to a neurotransmitter phenotype switch in developing neurons -- Miriam Salpeter Lecture -- 22. Miriam M Salpeter (Mika) â€? biographical notes -- 23. Chemical kinetics parameters and receptor degradation rates at the neuromuscular junction Summary The triennnial symposium on cholinergic mechanisms provides a key multidisciplinary forum for their interaction, and the proceedings of the XIth ISCM provide a cutting edge profile of research progress in this important field of research Notes "A Martin Dunitz Book." Bibliography Includes bibliographical references and index Notes Print version record Subject Cholinergic mechanisms -- Congresses Alzheimer's disease -- Congresses Autoimmune diseases -- Congresses Alzheimer's disease. Autoimmune diseases. Receptors, Cholinergic -- physiology Alzheimer Disease Autoimmune Diseases Synaptic Transmission -- physiology MEDICAL -- Neuroscience. PSYCHOLOGY -- Neuropsychology. Alzheimer's disease Autoimmune diseases Cholinergic mechanisms Genre/Form proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. Form Electronic book Author Silman, Israel. ISBN 0203493877 9780203493878 1280241047 9781280241048 9781135417505 1135417504 9781135417451 1135417458 9781135417499 1135417490

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