The heritage of pharmacology -- The scope of pharmacology -- How drugs act on the living organism -- How drugs reach their site of action. I. General principles of passage of drugs across biologic barriers. II. Absorption. III. Distribution -- How the actions of drugs are terminated. I. Excretion. II. Biotransformation -- General principles of the quantitative aspects of drug action. I. Dose-response relationships. II. Time-response relationships -- Factors modifying the effects of drugs in individuals. I. Variability in response attributable to the biologic system. II. Variability in response attributable to the conditions of administration -- Drug toxicity -- How drugs alter physiologic function -- The pharmacologic aspects of drug abuse -- The development and evaluation of new drugs -- Glossary -- Appendixes. 1. Drugs for treating gastrointestinal tract disorders. 2. Drugs for modifying renal function. 3. Drugs for treating infections and cancer. 4. Drugs for treating hypertension. 5. Drugs for reducing pain and consciousness. 6. Drugs for producing sedation and sleep. 6. Drugs for treating mood disorders. 7. Drugs for stimulating the central nervous system -- Index
