| Description |
1 online resource (xix, 418 pages) : illustrations |
| Contents |
Selecting the right targets for cancer therapy / Miguel H. Bronchud -- Clinical importance of prognostic factors: moving from scientifically interesting to clinically useful / N. Lynn Henry and Daniel F. Hayes -- Genetic markers in sporadic tumors / Elena Tamborini [and others] -- Genetic markers in breast tumors with hereditary predisposition / Tatyana A. Grushko and Olufunmilayo I. Olopade -- Circulating tumor markers / Alan Horwich and Gill Ross -- Antibody-based proteomics analysis of tumor cell signaling pathways / Steven Pelech and Hong Zhang -- Gene expression arrays for pathway analysis in cancer research / Xiang Sean Yu [and others] -- Signaling pathways in cancer / Daniel Kalderon -- Estrogen receptor pathways and breast cancer / Jing Peng and V. Craig Jordan -- Cyclin-dependent kinases and their regulators as potential targets for anticancer therapeutics / Marcos Malumbres -- Angiogenesis switch pathways / Jaume Piulats and Francesc Mitjans -- Apoptosis pathways and new anticancer agents / Frank A.E. Kruyt, Jose A. Rodriguez, and Giuseppe Giaccone -- Genomic instability, DNA repair pathways and cancer / Gabriel Capellá, Josep Balart, and Miquel Angel Peinado -- Epigenomics and cancer / Isabel Lopéz de Silanes and Manel Esteller -- Harnessing the power of immunity to battle cancer: Much ado about nothing or All's well that ends well? / Angelo A. Cardoso -- Aurora Kinases: a new target for anticancer drug development / Teresa Macarulla, Francisco Javier Ramos, and Josep Tabernero -- Emerging molecular therapies: drugs interfering with signal transduction pathways / Alison H.M. Reid, Richard Baird, and Paul Workman -- Suicide gene therapy / Silke Schepelmann, Ion Niculescu-Duvaz, and Caroline J. Springer -- Genotypes that predict toxicity and genotypes that predict efficacy of anticancer drugs / Rosario García-Campelo [and others] -- A personal account of the chemoprevention of breast cancer: possible or not possible? / V. Craig Jordan |
| Summary |
Drawing on years of significant scientific advances and clinical developments, the editors of POMO III have thoroughly updated the highly praised first and second editions and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, pharmacogenomics, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular-weight molecules. The first edition of this book (Humana Press, 2000) was also the first comprehensive presentation of the concept of cancer as a "disease process" involving key regulatory pathways. The second edition (2004) reaffirmed this dynamic concept, incorporating more recent evidence, and introducing such new topics of special interest as the combination of molecular diagnostics-expression profiling of genes and proteins- with developmental therapeutics, and the "binary state" concept (active/inactive) that seeks more relevant targets within the global molecular matrix of a given cancer. Comprehensive and intellectually stimulating, POMO III not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available. It fills a much neglected gap between "information" and "knowledge," and holds out the hope of new anticancer strategies that will reduce the process of carcinogenesis, cancer cell proliferation and significantly reduce metastasis |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Tumor markers.
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Carcinogenesis.
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Cancer -- Molecular aspects.
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Molecular Diagnostic Techniques
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Neoplasms -- prevention & control
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Biomarkers, Tumor
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Carcinogenesis
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Cancer -- Molecular aspects
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Carcinogenesis
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Tumor markers
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Neoplasias (prevenção e controle)
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| Form |
Electronic book
|
| Author |
Bronchud, Miguel H.
|
| ISBN |
9781597454704 |
|
1597454702 |
|
9781934115251 |
|
1934115258 |
|
