| Description |
1 online resource (xxii, 372 pages) : illustrations (some color) |
| Contents |
Overview of the HUPO Plasma Proteome Project : results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database / Gilbert S. Omenn [and others] -- Data management and preliminary data analysis in the pilot phase of the HUPO Plasma Proteome Project / Marcin Adamski [and others] -- HUPO Plasma Proteome Project specimen collection and handling : towards the standardization of parameters for plasma proteome samples / Alex J. Rai [and others] -- Immunoassay and antibody microarray analysis of the HUPO Plasma Proteome Project reference specimens : dystematic variation between sample types and calibration of mass spectrometry data / Brian B. Haab [and others] -- Depletion of multiple high-abundance proteins improves protein profiling capacities of human serum and plasma / Lynn A. Echan [and others] -- A novel four-dimensional strategy combining protein and peptide separation methods enables detection of low-abundance proteins in human plasma and serum proteomes / Hsin-Yao Tang [and others] -- A study of glycoproteins in human serum and plasma reference standards (HUPO) using multilectin affinity chromatography coupled with RPLC-MS/MS / Ziping Yang [and others] -- Evaluation of prefractionation methods as a preparatory step for multidimensional based chromatography of serum proteins / Eilon Barnea [and others] -- Efficient prefractionation of low-abundance proteins in human plasma and construction of a two-dimensional map / Sang Yun Cho [and others] -- Comparison of alternative analytical techniques for the characterisation of the human serum proteome in HUPO Plasma Proteome Project / Xiaohai Li [and others] -- A proteomic study of the HUPO Plasma Proteome Project's pilot samples using an accurate mass and time tag strategy / Joshua N. Adkins [and others] -- Analysis of Human Proteome Organization Plasma Proteome Project (HUPO PPP) reference specimens using surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry: multi-institution correlation of spectra and identification of biomarkers / Alex J. Rai [and others] -- An evaluation, comparison, and accurate benchmarking of several publicly available MS/MS search algorithms : sensitivity and specificity analysis / Eugene A. Kapp [and others] -- Human Plasma PeptideAtlas / Eric W. Deutsch [and others] -- Do we want our data raw? : including binary mass spectrometry data in public proteomics data repositories / Lennart Martens [and others] -- A functional annotation of subproteomes in human plasma / Peipei Ping [and others] -- Cardiovascular-related proteins identified in human plasma by the HUPO Plasma Proteome Project Pilot Phase / Beniam T. Berhane [and others] |
| Summary |
On the cutting edge of medical diagnostics, plasma proteomics promises to generate a new wave of technologies to help identify many different diseases and disease risks. Plasma and serum are the preferred non-invasive specimens to test normal individuals, at-risk groups, and patients for protein biomarkers discovered and validated to reflect physiological, pathological, and pharmacological phenotypes. These specimens present enormous challenges due to extreme complexity, huge dynamic range in protein concentrations, non-standardized methods of sample processing, and intra- and inter-individual |
| Notes |
Collection of articles published previously in the journal Proteomics |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Proteomics.
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Diagnostic Techniques and Procedures.
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Proteomics.
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| Form |
Electronic book
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| Author |
Omenn, Gilbert S.
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| ISBN |
3527609423 (electronic bk.) |
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3527609482 |
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9783527609420 (electronic bk.) |
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9783527609482 |
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(hd. bd.) |
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(hd. bd.) |
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