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Title Systems biology in cancer research and drug discovery / Asfar S. Azmi, editor
Published Dordrecht ; New York : Springer, [2012]
©2012
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Description 1 online resource
Contents pt. 1. Systems Biology in Cancer. Systems Biology Approach to Metabolomics in Cancer Studies / Mariano Bizzarri, Simona Dinicola and Cesare Manetti -- System Biology Approach to Study Cancer Related Pathways / Yike Guo and Xian Yang -- Modeling Oncogenic Signaling Networks from Gene Expression Dynamics / Aliccia Bollig-Fischer -- An Integrated Systems Approach to the Study of Pancreatic Cancer / Emanuela Gadaleta, Rosalind J. Cutts, Ajanthah Sangaralingam, Nicholas R. Lemoine and Claude Chelala -- Protein Microarray: An Ideal Platform for Systems Biology / Zong-Xiu Wang, Rui-Ping Deng, Shu-Juan Guo, Ji-Bin Zhang and Sheng-Ce Tao -- Systems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy Resistance / Sara Chiblak, Fevzi Demircioglu, Azadeh Fahim Golestaneh and Amir Abdollahi
pt. 2. System Approaches to Understanding Cancer. Understanding Cancer Progression Using Protein Interaction Networks / Emre Guney, Rebeca Sanz-Pamplona, Angels Sierra and Baldo Oliva -- Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach / M.M. Quinas-Guerra, T.M. Ribeiro-Rodrigues, Juan Carlos Rodríguez-Manzaneque and Rui D.M. Travasso -- Applications of Network Bioinformatics to Cancer Angiogenesis / Corban G. Rivera, Liang-Hui Chu, Joel S. Bader and Aleksander S. Popel
pt. 3. Systems and Network Biology in Decoding miRNA Complexity. Human MicroRNA Targetome Indicates a Specialized Role of MicroRNAs in Regulation of Oncogenesis / Jun-ichi Satoh -- Novel and Alternative Bioinformatics Approaches to Understand miRNA-mRNA Interactome in Cancer Research / Xiaohong Li, Carolyn M. Klinge and Susmita Datta -- Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA-Target Dysregulated Network / Xia Li, Juan Xu and Yongsheng Li
pt. 4. Network Modeling in Cancer Drug Discovery and Clinical Trials. Development and Clinical Implementation of Reverse Phase Protein Microarrays for Protein Network Activation Mapping: Personalized Cancer Therapy / Mariaelena Pierobon, Julie Wulfkuhle, Lance A. Liotta and Emanuel F. Petricoin III -- The Principle of Rational Design of Drug Combination and Personalized Therapy Based on Network Pharmacology / Jianghui Xiong, Simon Rayner, Fengji Liang and Yinghui Li -- Relevance of Network Hierarchy in Cancer Drug-Target Selection / Aritro Nath and Christina Chan -- Computational Infrastructures for Large-Scale Data Access and Analysis in Post-Genomic Clinical Trials / Manolis Tsiknakis -- Network Pharmacology: An Emerging Area in Anti-Cancer Drug Discovery / Asfar S. Azmi, Frances W.J. Beck, Bin Bao, Fazlul H. Sarkar and Ramzi M. Mohammad
Summary ""Systems Biology in Cancer Research and Drug Discovery"" provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology in understanding aberrant signaling in cancer; in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways; in unwinding microRNAs complexity; and in anticancer drug discovery and in clinical trial design. This book revie
Analysis Medicine
Oncology
Bioinformatics
Biological models
Biomedicine
Cancer Research
Systems Biology
Bibliography Includes bibliographical references and index
Notes English
Subject Cancer -- Research.
Systems biology.
Drug development.
Drugs -- Design.
Pharmacy -- Technological innovations.
Neoplasms.
Systems Biology -- methods.
Drug Discovery.
Research.
Form Electronic book
Author Azmi, Asfar S.
ISBN 9789400748194 (electronic bk.)
9400748191 (electronic bk.)
9400748183
9789400748187
9400794355
9789400794351