| Description |
1 online resource (1566 pages) : illustrations (some color) |
| Contents |
1. The Two Phases of Glucose-Stimulated Insulin Secretion: Mechanisms and Controls / Susanne G. Straub and Geoffrey W.G. Sharp -- 2. Insulin Gene Regulation / Michael German -- 3. Processing of the Insulin Molecule / Christopher J. Rhodes -- 4. Electrophysiology of the Pancreatic [beta]-Cell / Khaled Houamed, Jian Fu, Michael William Roe and Louis H. Philipson -- 5. Sulfonylurea Receptors, Andenosine Triphosphate-Sensitive Potassium Channels, and Insulin Secretion / Joseph Bryan and Lydia Aguilar-Bryan -- 6. Insulinotropic Glucagon-Like Peptides / Joel F. Habener and Daniel M. Kemp -- 7. Detrimental Effects of Chronic Hyperglycemia on the Pancreatic [beta]-Cell / Jack L. Leahy -- 8. Glucose Toxicity of the [beta]-Cell: Cellular and Molecular Mechanisms / P. Paul Robertson, Jamie Harmon, Yoshito Tanaka, Phuong Oanh Tran and Vincent Poitout -- 9. Lipotoxity / Roger H. Unger -- 10. Islet Amyloid in Type 2 Diabetes / Rebecca L. Hull and Steven E. Kahn -- 11. Physiologic Action of Insulin / Paul J. Flakoll, Michael D. Jensen and Alan D. Cherrington -- 12. Integration of Biochemical and Physiologic Effects of Insulin on the Control of Blood Glucose Concentrations / George Dimitriadis and Eric A. Newsholme -- 13. Glucose Counterregulatory Hormones: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia / Philip E. Cryer -- 14. The Role of Insulin Receptor Substrate Proteins in Insulin Signaling and Metabolic Regulation / Liangyou Rui and Morris F. White -- 15. The Insulin Signaling Network and Insulin Action / Yehiel Zick -- 16. Knockout Mice as a Tool to the Understanding of Diabetes Mellitus / Katrine Almind, Domenico Accili and C. Ronald Kahn -- 17. Regulation of Insulin Action by Protein-Tyrosine Phosphatases / Barry J. Goldstein -- 18. Small GTPases and Serine/Threonine Protein Kinase Cascades in Insulin Signal Transduction / Joseph Avruch -- 19. Protein Kinase C / Robert V. Farese -- 20. Regulation of Glycogen Synthesis / Alexander V. Skurat and Peter J. Roach -- 21. Insulin Action on Glucose Transport / Michael P. Czech, James L. Erwin and Mark W. Sleeman -- 22. Cellular and Molecular Processes Regulating Glucose Transporter 4 Translocation / June Chunqiu Hou, Alan R. Saltiel and Jeffrey E. Pessin -- 23. Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes / Constantine Londos -- 24. Role for Phosphodiesterase 3B in Regulation of Lipolysis and Insulin Secretion / Eva Degerman, Tova Rahn Landstrom, Lena Stenson Holst, Olga Goransson, Linda Harndahl, Faiyaz Ahmad, Young-Hun Choi, Silvia Masciarelli, Hanguan Liu and Vincent Manganiello -- 25. Gene Regulation / Richard M. O'Brien and Daryl K. Granner -- 26. Insulin Degradation / Richard A. Roth, Li Ding and Andrew Becker -- 27. Insulin and the Ras-Dependent Signaling Pathway / Marc L. Goalstone and Boris Draznin -- 28. Germline Manipulation of Glucose Transport and Glucose Homeostasis / Mike Mueckler -- 29. Molecular Links between Peroxisome Proliferator-Activated Receptor-[gamma] and Metabolic Disease / Gregg W. Van Citters and Barry M. Forman -- 30. Definition and Classification of Diabetes Mellitus and the Criteria for Diagnosis / Maureen I. Harris -- 31. The Natural History of Autoimmunity in Type 1A Diabetes Mellitus / Jennifer M. Barker and George S. Eisenbarth -- 32. Genetics of Type 1 Diabetes / Martin Hessner, Xujing Wang and Soumitra Ghosh -- 33. Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus / Lisa K. Gilliam, Jerry P. Palmer and Ake Lernmark -- 34. Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus / Alexander Rabinovitch -- 35. Major Histocompatibility Locus and Other Genes That Determine the Risk for Development of Type 1 Diabetes Mellitus / Massimo Pietropaolo and Massimo Trucco -- 36. Associations between Immune-Mediated (Type 1) Diabetes and Other Autoimmune Diseases / Svetlana Ten, Anjli Kukreja and Noel Maclaren -- 37. Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus / Ji-Won Yoon and Hee-Sook Jun -- 38. Animal Models of Autoimmune Diabetes Mellitus / John P. Mordes, David V. Serreze, Dale L. Greiner and Aldo A. Rossini -- 39. Insights from Transgenic and Gene Targeting Strategies in Type 1 Diabetes / Thomas W.H. Kay and Leonard C. Harrison -- 40. Diabetic Ketoacidosis and the Hyperglycemic Hyperosmolar Syndrome / Elizabeth D. Ennis and Robert A. Kreisberg -- 41. Application of the Diabetes Control and Complication Trial / Saul Genuth -- 42. Diet Therapy in Type 1 Diabetes Mellitus / Christine Beebe -- 43. Exercise for the Patient with Type 1 Diabetes Mellitus / Jeanne H. Steppel and Edward S. Horton -- 44. Insulin Therapy and Home Monitoring for Type 1 Diabetes Mellitus / Stuart J. Brink -- 45. Immune Intervention / Jay S. Skyler and Jennifer B. Marks -- 46. Islet Cell Transplantation / Antonello Pileggi, Rodolfo Alejandro, Daniel H. Mintz, Camillo Ricordi and Norma S. Kenyon -- 47. Islet Transplantation / Breay W. Paty, Edmond A. Ryan, Jonathan R.T. Lakey and A.M. James Shapiro -- 48. Pancreas Transplantation / David E.R. Sutherland, Rainer W.G. Gruessner, S. Michael Mauer and Angelika C. Gruessner -- 49. Gene Therapy for Metabolic Disease / Anthony T. Cheung and Timothy J. Kieffer -- 50. Surrogate [beta]-cells for Insulin Replacement Therapy / Christopher B. Newgard and Shimon Efrat -- 51. Stem Cells / Anandwardhan A. Hardikar and Marvin C. Gershengorn -- 52. Epidemiology of Type 2 Diabetes Mellitus / Dana Dabelea and Richard F. Hamman -- 53. Metabolic Abnormalities in the Development of Type 2 Diabetes Mellitus / P. Antonio Tataranni and Clifton Bogardus -- 54. Noninvasive Imaging of Insulin Action and Resistance in Humans / David E. Kelley and Frederico G.S. Toledo -- 55. Genetics of Human Obesity / Oluf Pedersen and Soren M. Echwald -- 56. Obesity: Treatment / Xavier Pi-Sunyer -- 57. Obesity in Type 2 Diabetes Mellitus / Henning Beck-Nielsen and Ole Hother-Nielsen -- 58. Effects of Aging Glucose Homeostasis / Annette M. Chang and Jeffrey B. Halter -- 59. Drug-Induced Diabetes Mellitus / Richard J. Comi -- 60. Insulin Secretion in Type 2 Diabetes Mellitus / Gordon C. Weir and Susan Bonner-Weir -- 61. Insulin Resistance and Its Consequences: Type 2 Diabetes Mellitus and the Insulin Resistance Syndrome / Gerald M. Reaven -- 62. Glucose Transporters and Pathophysiologic States / E. Dale Abel, Peter R. Shepherd and Barbara B. Kahn -- 63. Glucose Toxicity: Effect of Chronic Hyperglycemia on Insulin Action / Luciano Rossetti -- 64. Inflammation, Tumor Necrosis Factor-[alpha], and Insulin Resistance / Gokhan S. Hotamisligil -- 65. Adipokines: Regulators of Metabolic Integration and Energy Metabolism / Tsu-Shuen Tsao, Christopher Hug and Harvey F. Lodish -- 66. Fatty Acids and Insulin Resistance / Guenther Boden -- 67. Triglyceride in Muscle / Daniel T. Stein -- 68. Candidate Genes for Type 2 Diabetes Mellitus / Mona M. Sabra, Alan R. Shuldiner and Kristi D. Silver -- 69. Genetic Syndromes Associated with Severe Insulin Resistance: Mutations in the Insulin Receptor Gene and Lipotrophic Diabetes / Simeon I. Taylor, Elif Arioglu Oral and Domenico Accili -- 70. Maturity-Onset Diabetes of the Young: A Model for Genetic Studies of Diabetes Mellitus / Stefan S. Fajans and Graeme I. Bell -- 71. Rodent Genetic Models of Obesity and Type 2 Diabetes Mellitus / Marc L. Reitman -- 72. Primate Animal Models of Type 2 Diabetes / Barbara C. Hansen -- 73. Preventing Type 2 Diabetes: The Diabetes Prevention Program / David M. Nathan, Richard F. Hamman, Sanford Garfield, Anne Brenneman, Sarah F. Fowler and William C. Knowler -- 74. Dietary Therapy in Type 2 Diabetes Mellitus: Spreading the Nutrient Load / David J.A. Jenkins, Alexandra L. Jenkins, Livia S.A. Augustin and Cyril W.C. Kendall |
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75. Exercise in Patients with Type 2 Diabetes Mellitus / Jeanne H. Steppel and Edward S. Horton -- 76. Insulin Secretogogues: Sulfonylureas, Meglitinides, and Phenylalanine Derivatives / Harold E. Lebovitz -- 77. Metformin / Alan J. Garber -- 78. Peroxisome Proliferator-Activated Receptor Modulators / Garret J. Etgen, Melvin J. Prince and Jose F. Caro -- 79. [alpha]-Glucosidase Inhibitors in the Treatment of Diabetes / Markus Rupp -- 80. Glinides / James E. Foley and Lajwanti S. Khemlani -- 81. Combination Therapy in Type 2 Diabetes Mellitus / Stanley H. Hsia and Mayer B. Davidson -- 82. Intensive Insulin Therapy for Patients with Type 2 Diabetes / Sunder Mudaliar and Steven V. Edelman -- 83. Hypoglycemia in Type 2 Diabetes Mellitus / Mark R. Burge, Aruna Chelliah and David S. Schade -- 84. New Therapies to Promote Insulin Action / Guoqiang Jiang, Bei B. Zhang and David E. Moller -- 85. Intermediary Metabolism during Pregnancy: Implications for Diabetes Mellitus / Thomas A. Buchanan -- 86. Effects of Maternal Diabetes Mellitus on Intrauterine Development / Thomas A. Buchanan -- 87. Pregnancy and Complications of Diabetes Mellitus: Maternal and Fetal Implications / Barak M. Rosenn and Menachem Miodovnik -- 88. Gestational Diabetes Mellitus / Robert E. Ratner and Maureen D. Passaro -- 89. Pathophysiology of Diabetic Retinopathy / Emily Y. Chew -- 90. Pathogenesis of Diabetic Nephropathy / Gabriella Gruden, Luigi Gnudi and GianCarlo Viberti -- 91. Diabetic Neuropathies: An Overview of Clinical Aspects, Pathogenesis, and Treatment / Aaron I. Vinik, Gary L. Pittenger, Patricia Barlow and Anahit Mehrabyan -- 92. Diabetes Mellitus, Lipids, and Atherosclerosis / Clay F. Semenkovich -- 93. Pathophysiology of Hypertension in Diabetes Mellitus / Naftali Stern, James Sowers and Michael L. Tuck -- 94. Macrovascular Complications of Diabetes Mellitus / Helaine E. Resnick, Robert S. Lindsay and Barbara V. Howard -- 95. Skin and Diabetes / Efrat Wertheimer -- 96. Neonatal Diabetes Mellitus / Mark A. Sperling -- 97. Hypoglycemia in the Adult / Monica C. Skarulis and Boaz Hirshberg -- 98. Biochemistry and Molecular Cell Biology of Diabetic Complications: A Unifying Mechanism / Susanna Hofmann and Michael Brownlee -- 99. Hyperinsulinemia and Insulin Resistance / Ele Ferrannini -- 100. The Role of Growth Factors in the Pathogenesis of Diabetic Microvascular Complications / William L. Lowe, Jr. -- 101. Oxidative Stress, Inflammation, and Diabetic Complications / Milagros G. Huerta and Jerry L. Nadler -- 102. Diabetic Vasculopathy / S.I. McFarlane, P. Kumar, R. Muniyappa, F. El-Atat, A. Aneja and J.R. Sowers |
| Summary |
Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insu |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Issuing Body |
Digitized and made available by: Ovid Technologies |
| Notes |
Description based on print version record |
| Subject |
Diabetes -- Treatment.
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Diabetes -- Complications.
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Insulin.
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Diabetes.
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Diabetes Mellitus.
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Insulin -- physiology.
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| Author |
LeRoith, Derek, 1945- editor
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Taylor, Simeon I., editor
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Olefsky, Jerrold M., editor
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Brown, Brian, editor
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McMullan, Erin, editor
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Martin, Steven P., editor
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Abel, E. D. (E. Dale), contributor
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Ovid Technologies, Inc.
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| LC no. |
2003051690 |
| ISBN |
9781451166217 (e-book) |
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1451166214 (e-book) |
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0781740975 (hardcover) |
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9780781740975 (hardcover) |
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