| Description |
1 online resource (287 p.) |
| Contents |
Cover -- Title Page -- Copyright Page -- Contents -- Preface -- Chapter 1 Introduction to Ivermectin -- 1.1 Introduction -- 1.2 Sources and Synthesis -- 1.3 Pharmacological Potential of Ivermectin -- 1.3.1 Ivermectin in the Treatment of Cancer -- 1.3.1.1 Ovarian Cancer -- 1.3.1.2 Renal Cell Cancer -- 1.3.2 Ivermectin Against Viruses -- 1.3.3 Ivermectin in the Treatment of Bacterial Infections -- 1.4 Ivermectin's Beneficial Role in Cattle -- 1.5 Ivermectin in the Treatment of COVID-19 -- 1.5.1 Mode of Action -- 1.6 Toxicity of Ivermectin -- 1.6.1 Acute Toxicity |
|
1.6.2 Developmental and Reproduction Toxicity -- 1.6.3 General and Safety Pharmacology -- 1.7 Conclusion -- References -- Chapter 2 Historical Background of and Synthetic Approaches to Ivermectin (IVM) and its Homologues -- 2.1 Introduction -- 2.1.1 Historical Background of Ivermectin -- 2.2 Synthetic Approaches Towards the Construction of IVM and Analogues -- 2.3 Biosynthesis -- 2.4 Chemical Synthetic Pathway -- 2.5 Crystal Structure -- 2.6 Conclusion and Outlook -- Acknowledgements -- References -- Chapter 3 Ivermectin as a Repurposed Drug for COVID-19 -- 3.1 Introduction |
|
3.2 Symptoms of COVID-19 -- 3.3 Repurposing of the Drugs -- 3.4 Repurposed Drugs for COVID-19 -- 3.5 Repurposing of Ivermectin for COVID-19 -- 3.6 Proposed Possible Mechanism of Action -- 3.7 SARS COVID-19 Clinical Studies with Ivermectin -- 3.8 Conclusions -- 3.9 Acknowledgments -- References -- Chapter 4 Ivermectin as an Anti-Parasitic Agent -- Abbreviations -- 4.1 Introduction -- 4.2 Use of Ivermectin Against Various Human Parasitic Infections -- 4.2.1 Strongyloidiasis -- 4.2.2 Onchocerciasis -- 4.2.3 Lymphatic Filariasis -- 4.2.4 Loiasis -- 4.2.5 Scabies -- 4.2.6 Pediculosis |
|
4.2.7 Mansonellosis -- 4.2.8 Ascariasis -- 4.2.9 Gnathostomiases -- 4.2.10 Leishmaniasis -- 4.2.11 Malaria -- 4.3 Mode of Action Against Various Parasites -- 4.4 Conclusions -- 4.5 Acknowledgements -- References -- Chapter 5 Emerging Paradigm of Ivermectin and its Hybrids in Elimination of Malaria -- 5.1 Introduction -- 5.2 Malaria -- 5.2.1 World Malaria Report 2021 -- 5.2.2 Malaria in India: Statistics and Facts -- 5.2.3 Providing Malaria Treatment Despite All Odds -- 5.2.4 Meeting the Global Goal -- 5.2.5 Elimination of Malaria -- 5.2.6 Status of Anti-Malarial Drugs -- 5.3 Life Cycle of Malaria |
|
5.4 Drug Against Hepatic Malarial Stage -- 5.5 About Ivermectin -- 5.5.1 Ivermectin Against Liver Cells of Malaria Parasite -- 5.6 Designing and Synthesis of Ivermectin Inhibitors -- 5.6.1 Hybrids of Ivermectin -- 5.7 Conclusions -- 5.8 Acknowledgments -- References -- Chapter 6 Ivermectin: A Potential Repurposed Anti-Cancer Therapeutic -- Abbreviations -- 6.1 Introduction -- 6.2 Mechanism of Anti-Carcinogenesis -- 6.3 Activation of Chloride Ion Channels -- 6.4 Anti-Mitotic Effect and Inhibition of Angiogenesis -- 6.5 Inhibition of Mitochondrial Respiration |
| Notes |
Description based upon print version of record |
|
6.6 Inhibitor of Cancer Stem Cells (CSCs) |
| Form |
Electronic book
|
| Author |
ul-Islam, Shahid
|
| ISBN |
9781394168026 |
|
1394168020 |
|
