| Description |
1 online resource (viii, 268 pages) |
| Series |
Current topics in microbiology and immunology ; v. 349 |
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Current topics in microbiology and immunology ; v. 349.
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| Contents |
Understanding the Logic of I[MARC+6D]B:NF-[MARC+6D]b Regulation in Structural Terms / Gourisankar Ghosh -- NF-[MARC+6D]B/Rel Proteins and the Humoral Immune Responses of Drosophila melanogaster / Neal Silverman -- Specialized Chromatin Patterns in the Control of Inflammatory Gene Expression / Gioacchino Natoli -- IKK Regulation and Human Genetics / Alain Israel -- Control of NF-[MARC+6D]B Activity by Proteolysis / Emmanuel Derudder -- NF-[MARC+6D]B and Innate Immunity / Genhong Cheng -- NF-[MARC+6D]B and Mucosal Homeostasis / Andrew S. Neish -- IKK- and NF-[MARC+6D]B-Mediated Functions in Carcinogenesis / Florian R. Greten -- Macrophages and NF-[MARC+6D]B in Cancer / Toby Lawrence -- NF-[MARC+6D]B in Liver Cancer: The Plot Thickens / Eli Pikarsky -- NF-[MARC+6D]B as a Target for Oncogenic Viruses / Ethel Cesarman -- Inhibition of NF-[MARC+6D]B Signaling as a Strategy in Disease Therapy / Michael R. Garbati |
| Summary |
This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system |
| Analysis |
neoplasms |
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biomedische wetenschappen |
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biomedicine |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
NF-kappa B (DNA-binding protein)
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|
Transcription factors.
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NF-kappa B
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Transcription Factors
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SCIENCE -- Life Sciences -- Biochemistry.
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Transcription factors
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NF-kappa B (DNA-binding protein)
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| Form |
Electronic book
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| Author |
Karin, Michael.
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| ISBN |
9783642160172 |
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3642160174 |
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