| Description |
1 online resource (vii, 132 pages) : illustrations (some color) |
| Series |
Current Topics in Microbiology and Immunology, 0070-217X ; volume 373 |
|
Current topics in microbiology and immunology ; v. 373. 0070-217X
|
| Contents |
Development and Function of Cortical Thymic Epithelial Cells / Kensuke Takada, Izumi Ohigashi, Michiyuki Kasai, Hiroshi Nakase and Yousuke Takahama -- Mechanisms of Thymus Medulla Development and Function / Graham Anderson, Song Baik, Jennifer E. Cowan, Amanda M. Holland, Nicholas I. McCarthy [and 6 others] -- Self-Peptides in TCR Repertoire Selection and Peripheral T Cell Function / Wan-Lin Lo and Paul M. Allen -- Central Tolerance Induction / Maria L. Mouchess and Mark Anderson -- Trafficking to the Thymus / Shirley L. Zhang and Avinash Bhandoola -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes / Hirokazu Tanaka and Ichiro Taniuchi |
| Summary |
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 11, 2013) |
| Subject |
T cells.
|
|
Thymus -- Growth
|
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Thymus Gland -- growth & development
|
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T-Lymphocytes -- immunology
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Thymus Gland -- immunology
|
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SCIENCE -- Life Sciences -- Anatomy & Physiology.
|
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T cells
|
| Form |
Electronic book
|
| Author |
Boehm, Thomas, 1956- editor
|
|
Takahama, Yousuke, editor
|
| ISBN |
9783642402524 |
|
3642402526 |
|
3642402518 |
|
9783642402517 |
|
