| Description |
1 online resource (467 p.) |
| Series |
Drugs and the Pharmaceutical Sciences Ser |
|
Drugs and the Pharmaceutical Sciences Ser
|
| Contents |
Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- Editor Biographies -- Contributors -- Part I: Design and Control: Continuous Manufacturing of Small Molecule Drug Substances and Products -- Chapter 1: A Survey of Continuous API Syntheses: Insights at the Interface of Chemistry and Chemical Engineering -- 1.1 Introduction -- 1.2 Reaction Types That Lend Themselves for Continuous Processing -- 1.2.1 Highly Energetic Reactions -- 1.2.2 Diazomethane -- 1.2.3 Nitration Reactions -- 1.2.4 Oxidations -- 1.2.5 Azides |
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1.2.6 Organometallic Reactions -- 1.2.6.1 Fluconazole -- 1.2.6.2 Goniothalamin -- 1.3 Continuous Catalytic Reactions -- 1.3.1 Catalytic Hydrogenation Reactions -- 1.3.1.1 Thebaine (Hydrocodone) -- 1.3.1.2 Mepivacaine -- 1.3.1.3 API 1 (JAK2 Kinase Inhibitor by AstraZeneca) -- Augustine Method -- 1.3.1.4 N-4-Nitrophenyl Nicotinamide -- 1.3.1.5 Linezolid (Zyvox) -- 1.3.2 Cross-Coupling Reactions -- 1.3.2.1 Suzuki-Miyaura Cross-Coupling -- 1.3.3 Photochemical Organic Syntheses -- 1.3.3.1 Practical Flow Reactor Designs for Continuous Organic Photochemistry |
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1.3.3.2 Photochemical Flow Synthesis of Artemisinin -- 1.3.3.3 Photocatalysts as Alternatives to Precious Metal Catalysts -- 1.3.4 (R) and (S) Rolipram Paper -- 1.4 Total Syntheses of API -- 1.4.1 Significant Jump from Batch to Flow -- 1.4.1.1 Dolutegravir -- 1.4.1.2 Noroxymorphone -- 1.4.1.3 Ciprofloxacin -- 1.4.2 Greenness, Safety, PMI in Continuous Flow Processes -- 1.4.2.1 Nevirapine -- 1.4.2.2 1 H -4-Substituted Imidazoles -- 1.4.2.3 Daclatasvir -- 1.4.2.4 Iloperidone -- 1.4.3 Overcoming Challenges in Chemistry and Reaction Engineering with Flow -- 1.4.3.1 Ibuprofen -- 1.4.3.2 Benadryl |
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1.4.3.3 4,5-Disubstituted Oxazoles -- 1.4.3.4 Efavirenz -- 1.4.3.5 Hydroxychloroquine -- 1.4.3.6 Drug-Like Pyrrolidines Library -- 1.4.3.7 Endoperoxide OZ439 -- 1.4.3.8 KRAIC: Continuous Crystallization -- 1.4.3.9 AI Cloud-Based Server Designed Routes to Three APIs -- 1.4.3.10 Aliskiren: Continuous Preparation from Reagent to Finished Drug Tablet -- 1.4.3.11 Real-Time Monitoring of Continuous API Manufacturing with Cutting Edge PAT -- 1.5 Conclusion -- References -- Chapter 2: Development of Continuous Pharmaceutical Crystallization -- 2.1 Introduction: Background and Driving Forces |
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2.2 Basic Kinetics and Thermodynamic Principles in Crystallization -- 2.2.1 Solubility and Supersaturation -- 2.2.2 Nucleation and Growth -- 2.2.3 Mass and Population Balance Equation -- 2.3 Development and Application of Continuous Crystallizers -- 2.3.1 Single Stage and Cascades of Mixed Suspension Mixed Product Removal -- 2.3.2 Continuous Tubular Crystallizers -- 2.4 Monitoring and Controlling Continuous Pharmaceutical Crystallization via Process Analytical Technology -- 2.4.1 Process Monitoring and Analysis -- 2.4.2 Advances Crystallization Control Approaches |
| Notes |
Description based upon print version of record |
|
2.4.2.1 Model-Based Control Strategies |
| Form |
Electronic book
|
| Author |
Dubey, Atul
|
| ISBN |
9781000804478 |
|
100080447X |
|
