| Description |
1 online resource (x, 381 pages) : illustrations (some color) |
| Series |
Subcellular Biochemistry, 0306-0225 ; 74 |
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Sub-cellular biochemistry ; 74. 0306-0225
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| Contents |
Biology of Human Pathogenic Trypanosomatids: Epidemiology, Lifecycle and Ultrastructure / Juliany Cola Fernandes Rodrigues, Joseane Lima Prado Godinho and Wanderley de Souza -- Selection of Molecular Targets for Drug Development Against Trypanosomatids / Despina Smirlis and Milena Botelho Pereira Soares -- A2 and Other Visceralizing Proteins of Leishmania : Role in Pathogenesis and Application for Vaccine Development / Ana Paula Fernandes, Adriana Monte Cassiano Canavaci, Laura-Isobel McCall and Geg Matlashewski -- Arginase in Leishmania / Maria Fernanda Laranjeira da Silva and Lucile Maria Floeter-Winter -- The Heat Shock Proteins of Trypanosoma cruzi / Turán P. Ürményi, Rosane Silva and Edson Rondinelli -- The gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms / Cristian Cortez, Tiago J.P. Sobreira, Fernando Y. Maeda and Nobuko Yoshida -- The Gp85 Surface Glycoproteins from Trypanosoma cruzi / Eliciane C. Mattos, Renata R. Tonelli, Walter Colli and Maria Julia M. Alves -- Trypanosoma cruzi Trans -Sialidase: Structural Features and Biological Implications / Isadora A. Oliveira, Leonardo Freire-de-Lima, Luciana L. Penha, Wagner B. Dias and Adriane R. Todeschini -- Surface Topology Evolution of Trypanosoma Trans -Sialidase / Sergio Steven Cornejo Rubin De Celis -- Ecto-nucleotidases and Ecto-phosphatases from Leishmania and Trypanosoma Parasites / Anita Leocadio Freitas-Mesquita and José Roberto Meyer-Fernandes -- GP63 Function in the Interaction of Trypanosomatids with the Invertebrate Host: Facts and Prospects / Claudia M. d'Avila-Levy, Ellen C.F. Altoé, Lívia A. Uehara, Marta H. Branquinha and André L.S. Santos -- Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis / Carla Polycarpo -- The Expected Outcome of the Trypanosoma cruzi Proteomic Map: A Review of Its Potential Biological Applications for Drug Target Discovery / Rubem F.S. Menna-Barreto and Jonas Perales -- Proteomics Advances in the Study of Leishmania Parasites and Leishmaniasis / Jose Batista de Jesus, Camila Mesquita-Rodrigues and Patricia Cuervo -- Towards the Phosphoproteome of Trypanosomatids / Fabricio K. Marchini, Lyris Martins Franco de Godoy, Michel Batista [and 2 others] |
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Biology of Human Pathogenic Trypanosomatids: Epidemiology, Lifecycle and Ultrastructure -- Selection of Molecular Targets for Drug Development against Trypanosomatids -- A2 and other visceralizing proteins of Leishmania: role in pathogenesis and application for vaccine development -- Arginase in Leishmania -- The heat shock proteins of Trypanosoma cruzi -- The Gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms -- The Gp85 Surface Glycoproteins from Trypanosoma cruzi -- Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications -- Surface Topology Evolution of Trypanosoma Trans-Sialidase -- Ecto-Nucleotidases and Ecto-Phosphatases from Leishmania and Trypanosoma Parasites -- Gp63 Function in the Interaction of Trypanosomatids with the Invertebrate Host: Facts and Prospects -- Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis -- The Expected Outcome of the Trypanosoma cruzi Proteomic Map: a Review of its Potential Biological Applications for Drug Target Discovery -- Proteomics advances in the study of Leishmania parasites and leishmaniasis -- Towards the Phosphoproteome of Trypanosomatids |
| Summary |
This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids genera are etiological agents of leishmaniasis, Chagas' disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quite unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book "Proteins and Proteome of Leishmania and Trypanosoma" encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers |
| Notes |
Includes index |
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Online resource; title from PDF title page (SpringerLink, viewed November 25, 2013) |
| Subject |
Trypanosomatidae.
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Trypanosomiasis.
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Leishmaniasis.
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Medical parasitology.
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Protozoan Proteins -- metabolism
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Trypanosomatina -- pathogenicity
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Trypanosomatina -- immunology
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Trypanosomatina
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Trypanosomiasis
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Leishmaniasis
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Leishmaniasis
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Medical parasitology
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Trypanosomatidae
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Trypanosomiasis
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| Form |
Electronic book
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| Author |
Santos, Andre L. S., editor
|
| ISBN |
9789400773059 |
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9400773056 |
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