| Description |
1 online resource (498 pages) |
| Series |
Handbook of Clinical Neurology Ser. ; v. Volume 156 |
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Handbook of Clinical Neurology Ser
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| Contents |
Front Cover; Thermoregulation: From Basic Neuroscience To Clinical Neurology, Part I; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents of Part I; Contents of Part II; Section I: Thermoregulation system; Chapter 1: The thermoregulation system and how it works; Introduction: temperature and life1; Body temperatures; Core temperatures; Shell temperatures; Thermoregulatory effectors; The miscellany of physiologic and behavioral thermoeffectors; Heat exchange between the body and the environment; Conduction; Convection; Radiation; Evaporation |
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Thermoneutrality: a core concept of thermal physiologyThermoreceptors; Central thermoreceptors; Peripheral thermoreceptors and thermoTRP channels; Neural pathways; Afferent pathways of the physiologic thermoeffector responses; Efferent pathways of autonomic thermoeffector responses; Neural pathways of thermoregulatory behavioral responses; Putting it all together: how body temperature is regulated; Historic concepts of thermoregulation; A centralized control system with a single set point; Why the historic concepts needed revision; The current concept |
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Independent thermoeffector loops and their coordinationBalance point, not set point; Classification of thermoregulatory states; Fever and anapyrexia; Feedback -- main and auxiliary -- and feedforward; Different effectors are driven by different temperatures; Meshed control; Applying the new concept: thermopharmacology; The current concept is a consensus concept; The future of the consensus concept; Conclusions; Acknowledgments; Disclosure of potential conflicts of interest; References2; Section II: Thermoreceptors; Chapter 2: Peripheral thermoreceptors in innocuous temperature detection |
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IntroductionCold-sensitive afferent neurons innervating skin; Warm-sensitive afferent neurons innervating skin; Axonal thermosensitivity of thermoreceptive afferent neurons; Functional characteristics of thermosensitive afferents after nerve injury; Thermoreceptive afferent neurons encoding innocuous temperatures deep in the body; Is spinal cord warm sensitivity generated by stimulation of warm-sensitive spinal afferent neurons?; Acknowledgments; References; Chapter 3: Molecular basis of peripheral innocuous cold sensitivity; Introduction; Behavioral responses to cold temperatures; Human |
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Properties of cold-sensitive peripheral afferent sensory neuronsThe role of Na+ and K+ conductances in cold signaling; Detectors of cold in sensory neurons; A model for the cellular basis of cold sensation; Acknowledgments; References; Chapter 4: Molecular basis of peripheral innocuous warmth sensitivity; Introduction; TRPV1; TRPV3; TRPV4; TRPM2; TRPA1; Stromal interaction molecule 1 (STIM1); P2X3; Cyclic nucleotide-gated channels; Conclusions; Conflicts of interest; References; Chapter 5: Peripheral and central determinants of skin wetness sensing in humans; Introduction |
| Notes |
Skin wetness as a physiologic variable in human heat balance |
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Print version record |
| Subject |
Body temperature -- Regulation.
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Neurosciences.
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Neurology.
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Body Temperature Regulation
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Neurosciences
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Neurology
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Body temperature -- Regulation
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Neurology
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Neurosciences
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Neurologie
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Thermoregulation
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| Form |
Electronic book
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| ISBN |
9780444639134 |
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0444639136 |
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9780444640758 |
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0444640754 |
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