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Title Programmed cells from basic neuroscience to therapy / Fred H. Gage, Yves Christen, editors
Published Berlin ; New York : Springer, [2013]
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Description 1 online resource
Series Research and perspectives in neurosciences, 0945-6082 ; v. 20
Research and perspectives in neurosciences ; v. 20
Contents iPS Cell Technology and Disease Research: Issues To Be Resolved / Rudolf Jaenisch -- Therapeutic Somatic Cell Reprogramming by Nuclear Transfer / Stan Wang, John B. Gurdon -- Induction of Neural Lineages from Mesoderm and Endoderm by Defined Transcription Factors / Marius Wernig -- Proposing a Model for Studying Primate Development Using Induced Pluripotent Stem Cells / Maria C.N. Marchetto, Alysson R. Muotri -- HTT Evolution and Brain Development / Chiara Zuccato, Elena Cattaneo -- Human Pluripotent and Multipotent Stem Cells as Tools for Modeling Neurodegeneration / Jerome Mertens, Philipp Koch, Oliver Brüstle -- Human Stem Cell Approaches to Understanding and Treating Alzheimer's Disease / Lawrence S.B. Goldstein -- Potential of Stem Cell-Derived Motor Neurons for Modeling Amyotrophic Lateral Sclerosis (ALS) / Derek H. Oakley, Gist F. Croft -- Using Pluripotent Stem Cells to Decipher Mechanisms and Identify Treatments for Diseases That Affect the Brain / Marc Peschanski, Cécile Martinat -- Modeling Autism Spectrum Disorders Using Human Neurons / Alysson Renato Muotri -- On the Search for Reliable Human Aging Models: Understanding Aging by Nuclear Reprogramming / Ignacio Sancho-Martinez, Emmanuel Nivet
Summary The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed the experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson.s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. In addition, because PSC technology allows for the study of human neurons during development, disease-specific pathways can be investigated prior to and during disease onset. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, it is now feasible to obtain gene expression profiles from neurons that capture the genetic uniqueness of each patient. Importantly, once the neurological neural phenotype is detected in vitro, the so-called "disease-in-a-dish" approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases
Analysis Medicine
Stem cells
Notes Includes index
Bibliography Includes bibliographical references and index
Subject Neurosciences.
Cell Transplantation.
Stem Cells.
Form Electronic book
Author Gage, F. (Fred), 1950-
Christen, Yves.
LC no. 2013938743
ISBN 9783642366482 (electronic bk.)
3642366481 (electronic bk.)