| Description |
1 online resource : color illustrations |
| Series |
SpringerBriefs in neuroscience |
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SpringerBriefs in neuroscience.
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| Contents |
14. Neurosteroids and Convulsant Activity -- 14.1. Anticonvulsant Effects of Neurosteroids -- 14.2. Pro-Convulsant Effects of Neurosteroids -- 15. Roles in Tumors -- 16. Neurosteroids and the Spinal Cord -- 16.1. Protective and Restorative Functions of Neurosteroids in Injury -- 16.2. Neurosteroids in Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS) -- 17. Neurosteroids and the PNS -- 17.1. Schwann Cells and Myelination -- 17.2. Protective and Regenerative Roles in Injury -- 17.3. Demyelinating Diseases and Diabetic Neuropathy -- 18. Adrenal Chromaffin Cells and PC12 Cells -- 19. Integrated Actions of Neurosteroids in Nociception -- 19.1. 3[alpah]-Reduced Steroids and Thermal and Inflammatory Pain -- 19.2. Allopregnanolone and Neuropathic Pain -- 19.3. DHEA, DHEA-S, and Pregnenolone Sulfate -- 19.4. Ovarian Steroids -- 20. Mineralocorticoids and Glucocorticoids -- 20.1. Glucocorticoids -- 20.2. Aldosterone -- 21. Substance Abuse -- 22. Summary and Conclusions |
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1. Introduction -- 2. Steroidogenic Enzymes in the Nervous System -- 2.1. P450scc, StAR, and Neurosteroidogenesis -- 2.2. Peripheral Benzodiazepine Receptor/TSPO -- 2.3. StAR-Independent Steroidogenesis -- 2.4. DHEA, Sulfotransferase (SULT), and Sulfated Steroids -- 3. Regulation of De Novo Neurosteroidogenesis -- 4. Steroidogenic Pathways -- 5. Mechanism of Action of Neurosteroids -- 5.1. GABAA and GABAr Receptors -- 5.2. Glycine Receptors -- 5.3. [Sigma] Receptors -- 5.4. Ionotropic Glutamate Receptors -- 5.5. Transient Receptor Potential (TRP) Superfamily -- 5.6. Membrane Estrogen Receptors -- 5.7. Other Membrane Steroid Receptors -- 5.8. Other Receptors -- 6. Neurosteroid Functions -- 7. Neuronal Growth, Synaptic Plasticity, and Brain Development -- 7.1. Neurosteroid Production -- 7.2. Functional Effects of Neurosteroids |
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8. Neurosteroids, Anxiety, and Psychiatric Disorders -- 8.1. Anxiety and Stress -- 8.2. Therapeutic Synthetic Drugs Increase Neurosteroidogenesis -- 8.3. Depression -- 8.4. Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) -- 8.5. HRT and Mood -- 8.6. Other Psychiatric Disorders -- 9. Neurosteroids and Cognition -- 9.1. Promnesic Neurosteroids -- 9.2. Amnesic Neurosteroids -- 9.3. Age-Related Memory Changes and Neurosteroid Rescue -- 10. Neurosteroids and Reproduction -- 10.1. Female Reproduction -- 10.2. Female Sexual Behavior -- 10.3. Male Reproduction -- 10.4. Male Sexual Behavior -- 10.5. Male-Typical Behavior -- 11. Sleep, Anesthesia, and Hypnotic Effects -- 12. Other Functions -- 13. Neurosteroids in Disease and Injury -- 13.1. Neuroprotection in the Brain -- 13.2. Neurosteroids in Neurodegenerative Disorders in the Brain |
| Summary |
While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo ("neurosteroids"). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids |
| Analysis |
biomedische wetenschappen |
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biomedicine |
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neurochemie |
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neurochemistry |
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neurowetenschap |
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neuroscience |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Neuroendocrinology.
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Neurohormones.
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Neurotransmitters.
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Neuroendocrinology
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Neurotransmitter Agents
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Neurotransmitters
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Neuroendocrinology
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Neurohormones
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| Form |
Electronic book
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| ISBN |
9781461455592 |
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1461455596 |
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1461455588 |
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9781461455585 |
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