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Title Synaptic plasticity : dynamics, development and disease / Michael R. Kreutz, Carlo Sala, editors
Published Vienna ; New York : Springer, [2012]
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Description 1 online resource (ix, 618 pages) : illustrations
Series Advances in experimental medicine and biology, 0065-2598 ; 970
Advances in experimental medicine and biology ; 970
Contents Part 1. Molecular organization of the pre- and postsynaptic scaffold -- Glutamate Receptors in Synaptic Assembly and Plasticity: Case Studies on Fly NMJs -- Scaffold Proteins at the Postsynaptic Density -- Diversity of Metabotropic Glutamate Receptor-Interacting Proteins and Pathophysiological Functions -- Regulation of the Actin Cytoskeleton in Dendritic Spines -- Synaptic Cell Adhesion Molecules -- Part 2. Molecular dynamics of the synapse -- Molecular Dynamics of the Excitatory Synapse -- The Brain's Extracellular Matrix and Its Role in Synaptic Plasticity -- Molecular Motors in Cargo Trafficking and Synapse Assembly -- Surface Traffic in Synaptic Membranes -- Synaptic Protein Degradation in Memory Reorganization -- AMPA Receptor Assembly: Atomic Determinants and Built-In Modulators -- Developmental Plasticity of the Dendritic Compartment: Focus on the Cytoskeleton -- Dendritic mRNA Targeting and Translation -- Gliotransmission and the Tripartite Synapse -- Part 3. Synapse-to-nucleus communication -- Roles of Neuronal Activity-Induced Gene Products in Hebbian and Homeostatic Synaptic Plasticity, Tagging, and Capture -- Long-Distance Signaling from Synapse to Nucleus via Protein Messengers -- Nuclear Calcium Signaling -- Integrating Neurotransmission in Striatal Medium Spiny Neurons -- Part 4. Synaptic dysfunction and Synaptopathies -- Synaptic Dysfunction and Intellectual Disability -- Synaptic Pathology of Down Syndrome -- The Synaptic Pathology of Drug Addiction -- Synaptic Dysfunction in Schizophrenia -- Molecular and Cellular Aspects of Mental Retardation in the Fragile X Syndrome: From Gene Mutation/s to Spine Dysmorphogenesis -- Synaptic Dysfunction in Parkinson's Disease -- Synaptic Dysfunction in Alzheimer's Disease
Summary This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike
Analysis Medicine
Bibliography Includes bibliographical references and index
Subject Neuroplasticity.
Neuronal Plasticity.
Synapses -- physiology.
Form Electronic book
Author Kreutz, Michael R., 1961-
Sala, Carlo.
LC no. 2012932898
ISBN 9783709109328 (electronic bk.)
3709109329 (electronic bk.)
3709109310 (hbk.)
9783709109311 (hbk.)