Title Reducing mortality in the perioperative period / Giovanni Landoni, Laura Ruggeri, Alberto Zangrillo, editors

Published Cham : Springer, 2014

Table of Contents
1.	The Risks and Benefits of the Consensus Process / Rinaldo Bellomo					1
1.1.	Introduction					1
1.2.	The Current Consensus Process					3
1.3.	New Approaches to Consensus Development					4
1.4.	Conclusions					6
	References					6
2.	The Process of Consensus Building / Luca Cabrini					9
2.1.	Step 1. Evidence Collection and Analysis					10
2.2.	Step 2. Web-Based Polling and First Consensus Building					12
2.3.	Step 3. Consensus Meeting					12
2.4.	Step 4. Second Web-Based Polling					14
2.5.	Step 5. Article Publication					14
2.6.	What's Next					14
	References					15
3.	Noninvasive Ventilation to Reduce Perioperative Mortality / Laura Ruggeri					17
3.1.	Background					17
3.2.	Evidences from Literature					18
3.2.1.	Thoracic Surgery					18
3.2.2.	Cardiac Surgery					19
3.2.3.	Abdominal Surgery					19
3.2.4.	Solid Organ Transplantation					20
3.3.	Therapeutic Use					20
3.3.1.	Ventilation Strategies					20
3.3.2.	Patient--Ventilator Interface					20
3.3.3.	Complications					21
3.4.	Conclusions					21
	References					22
4.	Role of Inhalational Anesthetic Agents in Reducing Perioperative Mortality / Laura Ruggeri					25
4.1.	General Principles					25
4.2.	Main Evidences					25
4.3.	Pharmacologic Properties					26
4.4.	Therapeutic Use					26
4.4.1.	Myocardial Protection in Patients Undergoing Surgery Under Cardiopulmonary Bypass					26
4.4.2.	Myocardial Protection in Patients Undergoing Off-Pump Coronary Artery Bypass					27
4.4.3.	Cardiac Patients Undergoing Noncardiac Surgery					28
4.4.4.	Potential for Protection of Patients with Ischemic Heart Disease, Myocardial Infarction and Undergoing Coronary Artery Stent Procedures					28
4.5.	Conclusions					28
	References					29
5.	Can Neuraxial Anesthesia Reduce Perioperative Mortality? / John G. T. Augoustides					31
5.1.	Introduction					31
5.2.	Main Evidence					32
5.2.1.	Orthopedic Surgery					32
5.2.2.	Vascular Surgery					32
5.2.3.	Cardiac Surgery					33
5.2.4.	Cancer Surgery					33
5.3.	Conclusions					34
	References					34
6.	Role of Perioperative Hemodynamic Optimization in Reducing Perioperative Mortality / Agostino Roasio					37
6.1.	General Principles					37
6.2.	Main Evidences					37
6.3.	Physiopathology					38
6.4.	Therapeutic Use					44
6.5.	Conclusions					46
	References					46
7.	Levosimendan to Reduce Perioperative Mortality / Daniela Mamo					49
7.1.	General Principles					49
7.2.	Main Evidences					50
7.3.	Pharmacologic Properties					51
7.4.	Therapeutic Use					52
7.4.1.	Intermittent Administration					53
7.4.2.	Possible Future Targets					53
7.5.	Conclusions					53
	References					54
8.	Could Clonidine Contribute to a Reduction in Perioperative Mortality? / Enrico M. Camporesi					57
8.1.	Introduction					57
8.2.	Published Evidence					58
8.3.	Therapeutic Administration					61
8.4.	Conclusions					62
	References					63
9.	Perioperative β-Blocker Therapy and Survival / Enrico M. Camporesi					67
9.1.	General Principles					67
9.2.	Main Evidences					68
9.2.1.	Randomized β-Blocker Studies Outcome					68
9.2.2.	AHA and ESC Guideline Controversies					68
9.2.3.	Common Recommendations Between Both Societies					70
9.2.4.	Recommendations Differing Between Both Societies					70
9.3.	Pharmacologic Properties					72
9.3.1.	When to Start β-Blocker Therapy, Which β-Blocker, and What are the Goals					72
9.3.2.	Discontinuing β-Blockers					72
9.4.	Summary of Recommendations					72
	References					74
10.	Perioperative Supplemental Oxygen to Reduce Perioperative Mortality / Antonella Capasso					77
10.1.	General Principles					77
10.2.	Main Evidences					78
10.3.	Pharmacologic Properties					80
10.4.	Therapeutic Use					81
10.5.	Conclusions					82
	References					83
11.	Leukocyte Depletion of Transfused Blood to Reduce Perioperative Mortality / Antonio Pisano					85
11.1.	General Principles					85
11.2.	Main Evidences					86
11.3.	Pharmacologic Properties					88
11.4.	Therapeutic Use					90
11.5.	Conclusions					90
	References					91
12.	Chlorhexidine Oral Rinse to Reduce Perioperative Mortality / Antonella Capasso					93
12.1.	General Principles					93
12.2.	Main Evidences					94
12.3.	Pharmacologic Properties					95
12.4.	Therapeutic Use					97
12.5.	Conclusions					98
	References					98
13.	Reducing Perioperative Mortality with Intra-Aortic Balloon Counterpulsation (IABP) / George Silvay					101
13.1.	General Principles					101
13.2.	Therapeutic Application					102
13.3.	Main Evidences					102
13.3.1.	Cardiac Surgery					102
13.3.2.	Non-cardiac Surgery					102
13.3.3.	Percutaneous Coronary Intervention					103
13.4.	Conclusions					104
	References					104
14.	Selective Decontamination of the Digestive Tract / Hendrick K. F. van Saene					107
14.1.	General Principles					107
14.2.	Main Evidence					107
14.3.	Pharmacologic Properties					109
14.4.	Therapeutic Use					109
14.5.	Conclusions					111
	References					113
15.	Role of Insulin in Reducing Mortality in the Perioperative Period / Maciej T. Wybraniec					115
15.1.	General Principles					115
15.2.	Main Evidences					116
15.3.	Pharmacologic Properties					117
15.4.	Therapeutic Use					117
15.4.1.	Insulin Solutions					118
15.4.2.	Pharmacokinetics					118
15.4.3.	Perioperative Therapy, Route of Administration, and Dosing					118
15.4.4.	Side Effects and Toxicity					120
15.5.	Conclusions					120
	References					122
16.	Aprotinin: Pharmacological Benefits and Safety Concerns / Bela Merkely					125
16.1.	General Principles					125
16.2.	Pharmacologic Properties					126
16.3.	Therapeutic Use					126
16.4.	Main Evidences					127
16.5.	Conclusions					129
	References					129
17.	Consensus Conference on Perioperative Mortality: An Update / Giovanni Landoni					131
17.1.	Blood Volume Analysis-Guided Resuscitation					132
17.2.	Levosimendan					132
17.3.	Aprotinin					133
17.4.	Tranexamic Acid					133
17.5.	Preoperative Intra-Aortic Balloon Pump					134
17.6.	Perioperative Supplemental Oxygen					134
17.7.	Intensive Insulin Treatment					135
17.8.	Conclusions					135
	References					135
	Index					137

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Description 1 online resource (xi, 139 pages) : illustrations (some color) Contents 880-01 The risks and benefits of the consensus process -- The process of consensus building -- Noninvasive Ventilation to reduce perioperative mortality -- Role of inhalational anesthetic agents in reducing perioperative mortality -- Can Neuraxial Anesthesia Reduce Perioperative Mortality -- Role of perioperative hemodynamic optimization in reducing perioperative mortality -- Levosimendan to reduce perioperative mortality -- Could Clonidine Contribute to a Reduction in Perioperative Mortality -- Perioperative [beta]-blocker therapy to improve survival -- Perioperative supplemental oxygen to reduce perioperative mortality -- Leukocyte depletion of transfused blood to reduce perioperative mortality -- Chlorhexidine Oral Rinse to reduce perioperative mortality -- Reducing perioperative mortality with Intra Aortic Balloon Counterpulsation (IABP) -- Selective Decontamination of the Digestive Tract -- Role of insulin in reducing mortality in the perioperative period -- Aprotinin: pharmacological benefits and safety concerns -- Consensus Conference on perioperative mortality: an update 880-01/(S The risks and benefits of the consensus process / Rinaldo Bellomo -- The process of consensus building / Massimiliano Greco, Pier Carlo Bergonzi and Luca Cabrini -- Noninvasive ventilation to reduce perioperative mortality / Paolo Feltracco, Daniela Pasero and Laura Ruggeri -- Role of inhalational anesthetic agents in reducing perioperative mortality / Murali Chakravarthy and Laura Ruggeri -- Can neuraxial anesthesia reduce perioperative mortality? / Caetano Nigro Neto, Alexandre Slullitel and John G.T. Augoustides -- Role of perioperative hemodynamic optimization in reducing perioperative mortality / Agostino Roasio -- Levosimendan to reduce perioperative mortality / Massimiliano Greco, Gianluca Paternoster and Daniela Mamo -- Could clonidine contribute to a reduction in perioperative mortality? / Massimiliano Conte, Roberto Martino and Enrico M. Camporesi -- Perioperative β-blocker therapy and survival / Hesham R. Omar, Devanand Mangar and Enrico M. Camporesi -- Perioperative supplemental oxygen to reduce perioperative mortality / Antonio Pisano and Antonella Capasso -- Leukocyte depletion of transfused blood to reduce perioperative mortality / Antonella Capasso and Antonio Pisano -- Chlorhexidine oral rinse to reduce perioperative mortality / Antonio Pisano and Antonella Capasso -- Reducing perioperative mortality with intra-aortic balloon counterpulsation (IABP) / John G.T. Augoustides, Aris Sophocles and George Silvay -- Selective decontamination of the digestive tract / Luciano Silvestri and Hendrick K.F. van Saene -- Role of insulin in reducing mortality in the perioperative period / Łukasz J. Krzych and Maciej T. Wybraniec -- Aprotinin: pharmacological benefits and safety concerns / Andrea Székely, Daniel J. Lex and Béla Merkely -- Consensus conference on perioperative mortality: an update / Marta Mucchetti and Giovanni Landoni Summary This book describes the techniques, strategies, and drugs that have been demonstrated by well-documented randomized trials to influence survival in the perioperative setting. It takes into consideration all types of adult surgery and will be relevant to the evaluation of any patient undergoing an operative procedure. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as chlorhexidine oral rinse, clonidine therapy, insulin infusion, intra-aortic balloon pump support, leukodepletion, neuraxial anesthesia, and noninvasive respiratory support, to name but a few. In addition, the risks and benefits of using a web-based consensus process (as in this book) to identify effective means of reducing perioperative mortality are discussed. The clear text is supported by "how to do" sections and "key points" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in the Perioperative Period will be of interest for a wide variety of specialists, including surgeons, cardiologists, anesthesiologists, and intensivists Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (SpringerLink, viewed November 25, 2013) Subject Postoperative care. Surgery -- Complications. Perioperative Period -- mortality Perioperative Care -- mortality Surgical Procedures, Operative -- mortality Postoperative Complications -- mortality Postoperative Care Postoperative Complications MEDICAL -- Surgery -- General. Médecine. Postoperative care Surgery -- Complications Form Electronic book Author Landoni, Giovanni, editor Ruggeri, Laura, editor Zangrillo, Alberto, editor ISBN 9783319021867 3319021869 3319021850 9783319021850

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