| Description |
1 online resource (xiv, 202 pages) : illustrations (some color) |
| Series |
Springer protocols |
|
Methods in molecular biology, 1064-3745 ; 480 |
|
Springer protocols (Series)
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Methods in molecular biology (Clifton, N.J.) ; v. 480
|
| Contents |
Developments in macromolecular drug delivery / Mattias Belting and Anders Wittrup -- Synthetic vs. natural/biodegradable polymers for delivery of shRNA-based cancer therapies / John S. Vorhies and John J. Nemunaitis -- siRNA and DNA transfer to cultured cells / Bagavathi Gopalakrishnan and Jon Wolff -- Poly ([beta]-amino esters) : procedures for synthesis and gene delivery / Jordan J. Green [and others] -- Systemic delivery and pre-clinical evaluation of nanoparticles containing antisense oligonucleotides and siRNAs / Chuanbo Zhang [and others] -- Peptide-based delivery of steric-block PNA oligonucleotides / Saïd Abes [and others] -- Characterizing peptide-mediated DNA internalization in human cancer cells / Anders Wittrup and Mattias Belting -- Selection and characterization of antibodies from phage display libraries against internalizing membrane antigens / Johan Fransson and Carl A.K. Borrebaeck -- Artificial membrane models for the study of macromolecular delivery / Lena Mäler and Astrid Gräslund -- Enhanced delivery of macromolecules into cells by electroendocytosis / Alexander Barbul [and others] -- In vitro systems for studying epithelial transport of macromolecules / Nicole Daum [and others] -- Preparation of macromolecule-containing dry powders for pulmonary delivery / Kelly S. Kraft and Marshall Grant -- Macromolecular delivery across the blood-brain barrier / Kullervo Hynynen -- Positron emission tomography (PET) and macromolecular delivery in vivo / Ludwig G. Strauss and Antonia Dimitrakopoulou-Strauss |
| Summary |
Macromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular Biology series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases |
| Analysis |
geneesmiddelen |
|
drugs |
|
geneesmiddeltoedieningssystemen |
|
drug delivery systems |
|
farmacie |
|
pharmacy |
|
geneeskunde |
|
medicine |
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Pharmacology |
|
Farmacologie |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Drug delivery systems.
|
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Drug Delivery Systems
|
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Macromolecular Substances
|
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Drug delivery systems
|
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Systèmes de libération d'un principe actif -- Cahiers de laboratoire.
|
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Structures macromoléculaires -- Cahiers de laboratoire.
|
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Vecteurs de médicaments.
|
| Genre/Form |
Laboratory manuals
|
|
Laboratory manuals.
|
|
Manuels de laboratoire.
|
| Form |
Electronic book
|
| ISBN |
9781597454292 |
|
159745429X |
|
