| Description |
1 online resource (xxxv, 582 pages) : illustrations |
| Series |
Methods in enzymology ; v. 408 |
|
Methods in enzymology ; v. 408
|
| Contents |
Acknowledgments References; Chapter 6. The adipocyte and adipose tissue as endocrine organs: Impact on the insulin resistance phenotype; 1. Embryonic development of adipose tissue and the role of angiogenesis; 2. Expansion of adiose tissue mass: hypertrophy versus hyperplasia and impact on adipocyte function; 3. Adipose tissue distribution and its relation to metabolism-depot specificity; 4. Impact of PPAR agonists on adipokines in disease states; References; Chapter 7. FOXC2 in the adipocyte; 1. Introduction; 2. The gene and its expression profile; 3. Function in metabolism; 5. The LXRs are anti-atherosclerotic and anti-inflammatory factors; 6. Cross-talk between the LXRs and other NRs regulates overall body homeostasis; 7. Perspectives; References; Chapter 5. SREBP-1c regulation of nutrient homeostasis and lipid accumulation; 1. Introduction; 2. Structure, genes and tissue distribution of SREBP isoforms; 3. Regulation of SREBP-1c transcriptional activity; 4. SREBP target genes; 5. Mechanisms involved in glucose action: involvement of the ''Carbohydrate Response Element Binding Protein'' transcription factor; 6. SREBPs and physiopathology; 7. Conclusion; 4. Regulation of FOXC25. WAT versus BAT; 6. Protection against diet-induced insulin resistance; 7. Human data; 8. The autonomic nervous system; 9. Future; Acknowledgment; References; Chapter 8. Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors; 1. Introduction; 2. Roles for Wnt signaling in adipogenesis and glucose homeostasis; 3. Role of C/EBPS in hepatocyte differentiation and liver metabolism; 4. Roles for C/EBPs in adipocyte differentiation and metabolism; Acknowledgments; References |
| Summary |
This volume provides detailed coverage of modern methods for molecular analysis of enzymes and enzyme systems that function in the maintenance of genome integrity. Coverage areas include base excision repair, nucleotide excision repair, translesion DNA polymerases, mismatch repair, genetic recombination, and double strand break repair. *A laboratory standard for more than 40 years *Over 400 volumes strong *Also available on <a href="http://www.sciencedirect.com">ScienceDirect</a> *Part A of a 2-part series |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Print version record |
| Subject |
Enzymology.
|
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DNA repair.
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DNA Repair.
|
| Form |
Electronic book
|
| Author |
Campbell, Judith L.
|
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Modrich, Paul.
|
| ISBN |
9780080463551 (electronic bk.) |
|
008046355X (electronic bk.) |
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0121828131 (electronic bk.) |
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9780121828134 (electronic bk.) |
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0121828123 |
|
9780121828127 |
|
1280635827 |
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9781280635823 |
|
