| Description |
1 online resource (ix, 533 pages) : illustrations |
| Contents |
880-01 Mission oriented research: An experience in Dr. Jack J. Fox's laboratory -- Development of new radical reactions with a vinylsilyl group and their application to the synthesis of branched-chain sugar nucleosides -- Synthesis of purine acyclonucleosides via ribofuranose-ring cleavage of purine nucleosides by diisobutylaluminum hydride -- The chemistry of nucleoside and dinucleotide inhibitors of nosine monophosphate dehydrogenase (IMPDH) -- Nucleoside and Nucleotide Prodrugs -- Antiviral Isonucleosides: Discovery, Chemistry and Chemical Biology -- Synthesis and Biological Activity of Isopolar Acyclic Nucleotide Analogs -- Synthesis of Pyranose Nucleosides and Related Nucleosides With a Six-Membered Carbohydrate Mimic -- 5'-Norcarbanucleosides in L-Like Configurations -- Tricyclic Nucleosides Revisited -- Unusual Analogues of Nucleosides: Chemistry and Biological Activity -- Lithiation-Based Silylation and Stannylation for Nucleoside Synthesis -- Purine Metabolism in Parasites: Potential Targets for Chemotherapy -- Antiviral [beta]-L-Njucleosides Specific for Hepatitis B Virus Infection -- Antivifral Activity of Nucleoside Amnalogues: The BVDU Connection -- The Role of the Cellular Deoxynucleoside Kinases in Activation of Nucleoside Analogs Used in Chemotherapy -- Cellular Transport of Nucleottide Analogs -- 5-AZA-7-Deazapurines: Synthesis and Properties of Nucleosides and Oligonucleotides |
|
880-01/(S Mission Oriented Research: An Experience in Dr. Jack J. Fox's Laboratory / Kyoichi A. Watanabe -- Development of New Radical Reactions with a Vinylsilyl Group and Their Application to the Synthesis of Branched-Chain Sugar Nucleosides / Satoshi Shuto, Makiko Kanazaki, Isamu Sugimoto, Satoshi Ichikawa, Yuki Nagasawa, Yoshihito Ueno, Hiroshi Abe, -- viaSynthesis of Purine Acyclonucleosides Ribofuranose-Ring Cleavage of Purine Nucleosides By Diisobutylaluminum Hydride / Kosaku Hirota, Yasunari Monguchi, Hironao Sajiki -- The Chemistry of Nucleoside and Dinucleotide Inhibitors of Inosine Monophosphate Dehydrogenase (IMPDH) / Krzysztof W. Pankiewicz, Barry M. Goldstein -- Nucleoside and Nucleotide Prodrugs / John S. Cooperwood, Giuseppe Gumina, F. Douglas Boudinot, Chung K. Chu -- Antiviral Isonucleosides: Discovery, Chemistry and Chemical Biology / Vasu Nair -- Synthesis and Biological Activity of Isopolar Acyclic Nucleotide Analogs / Antonín Holý -- Synthesis of Pyranose Nucleosides and Related Nucleosides With a Six-Membered Carbohydrate Mimic / Piet Herdewijn -- 5'-Norcarbanucleosides in L-Like Configurations / Stewart W. Schneller, Katherine L. Seley, Vishnumurthy R. Hegde, Vasanthakumar P. Rajappan -- Tricyclic Nucleosides Revisited / Katherine L. Seley -- Unusual Analogues of Nucleosides: Chemistry and Biological Activity / Jiri Zemlicka -- Lithiation-Based Silylation and Stannylation for Nucleoside Synthesis / Hiroki Kumamoto, Keisuke Kato, Hiromichi Tanaka -- Purine Metabolism in Parasites: Potential Targets for Chemotherapy / Mahmoud H. El Kouni -- Antiviral β-L-Nucleosides Specific for Hepatitis B Virus Infection / Jean-Pierre Sommadossi -- Antiviral Activity of Nucleoside Analogues: The BVDU Connection / Erik De Clercq -- The Role of the Cellular Deoxynucleoside Kinases in Activation of Nucleoside Analogs Used in Chemotherapy / Staffan Eriksson, Liya Wang -- Cellular Transport of Nucleotide Analogs / Tomas Cihlar, Damian Mccoll, Norbert Bischofberger -- 5-AZA-7-Deazapurines: Synthesis and Properties of Nucleosides and Oligonucleotides / Frank Seela, Helmut Rosemeyer |
| Summary |
The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs |
| Analysis |
nucleosiden |
|
nucleosides |
|
chemische eigenschappen |
|
chemical properties |
|
geneesmiddelenbehandeling |
|
drug therapy |
|
Nucleic Acids |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| Subject |
Nucleosides -- Synthesis
|
|
Nucleosides -- Therapeutic use
|
|
Nucleosides -- chemistry
|
|
Nucleosides -- therapeutic use
|
|
MEDICAL -- Pharmacology.
|
|
Nucleosides -- Synthesis
|
|
Nucleosides -- Therapeutic use
|
| Form |
Electronic book
|
| Author |
Chu, Chung K.
|
| ISBN |
9780444509512 |
|
0444509518 |
|
9780080540368 |
|
0080540368 |
|
