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Title Structural and functional organization of the synapse / edited by Johannes W. Hell and Michael D. Ehlers
Published New York : Springer, [2008]
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Description 1 online resource (xviii, 801 pages) : illustrations (some color)
Contents Diversity in synapse structure and composition / Kristen M. Harris -- The role of glutamate transporters in synaptic transmission / Dwight E. Bergles and Robert H. Edwards -- Structure and function of vertebrate and invertebrate active zones / Craig C. Garner and Kang Shen -- Neurotransmitter release machinery: components of the neuronal SNARE complex and their function / Deniz Atasoy and Ege T. Kavalali -- The molecular machinery for synaptic vesicle endocytosis / Peter S. McPherson, Brigitte Ritter and George J. Augustine -- Initiation and regulation of synaptic transmission by presynaptic calcium channel signaling complexes / Zu-Hang Sheng, Amy Lee and William A. Catterall -- Adhesion molecules at the synapse / Alaa El-Husseini -- Dendritic organelles for postsynaptic trafficking / Cyril Hanus and Michael D. Ehlers -- Structure and mechanism of action of AMPA and kalnate receptors / Mark L. Mayer -- Cellular biology of AMPA receptor trafficking and synaptic plasticity / Jose A. Esteban -- Structure and function of the NMDA receptor / Hongjie Yuan [and others] -- Molecular properties and cell biology of the NMDA receptor / Robert J. Wenthold [and others] -- Surface trafficking of membrane proteins at excitatory and inhibitory synapses / Daniel Choquet and Antoine Triller -- Scaffold proteins in the postsynaptic density / Mary B. Kennedy, Edoardo Marcora and Holly J. Carlisle -- Ca² signaling in dendritic spines / Bernardo L. Sabatini and Karel Svoboda -- Postsynaptic targeting of protein kinases and phosphatases / Stefan Strack and Johannes W. Hell -- Long-term potentiation / John E. Lisman and Johannes W. Hell -- Homeostatic synaptic plasticity / Gina G. Turrigiano -- Ubiquitin and protein degradation in synapse function / Thomas D. Helton and Michael D. Ehlers -- Signaling from synapse to nucleus / Carrie L. Heusner and Kelsey C. Martin -- Molecular organization of the postsynaptic membrane at inhibitory synapses / I. Lorena Arancibia-Carcamo, Antoine Triller and Josef T. Kittler -- Acid-sensing ion channels (ASICs) and pH in synapse physiology / John A. Wemmie, Xiang-ming Zha and Michael J. Welsh -- Glia as active participants in the development and function of synapses / Cagla Eroglu, Ben A. Barres and Beth Stevens -- Plasticity of dentate granule cell mossy fiber synapses: a putative mechanism of limbic epileptogenesis / James O. McNarnara, Yang Z. Huang and Enhui Pan -- Stroke -- a synaptic perspective / Robert Meller and Roger P. Simon -- Neuroplasticity and pathological pain / Michael W. Salter
Summary The synapse is a fundamental subcellular structure in the brain connecting neurons with each other. It transmits information from one neuron to another and is also involved in data processing and storage. The synapse is the site where neurons communicate with each other. A synapse is a small gap that physically separates neurons. This book is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate functional aspects to molecular mechanisms. This approach provides a sense of which mechanisms are characterized on both the functional a
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Synapses.
Synaptic Transmission.
Form Electronic book
Author Ehlers, Michael D.
Hell, Johannes W.
ISBN 0387772324 (electronic bk.)
9780387772325 (electronic bk.)