| Description |
1 online resource (xi, 83 pages) : illustrations (some color), color maps |
| Series |
SpringerBriefs in immunology, 2194-2773 |
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SpringerBriefs in immunology.
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| Contents |
1. Introduction -- Historical Background of Leishmania and Leishmaniasis -- Risk Factors and Definition of the Problem -- Types of Leishmaniasis -- Cutaneous Leishmaniasis (CL) -- Diffuse Cutaneous Leishmaniasis (DCL) -- Mucocutaneous Leishmaniasis (MCL) -- Visceral Leishmaniasis (VL) or Kala-azar (KA) -- Geographical Distribution of Leishmaniasis -- Global Status of Visceral Leishmaniasis (Kala-azar) -- Morphology and Life Cycle of Leishmania donovani -- Vectors and Transmission of the Disease -- Clinical Symptoms of Visceral Leishmaniasis -- Control Strategies of the Disease -- Leishmania/HIV Co-infections -- 2. Immunology of Leishmania -- Role of B Cells and Immunoglobulin -- Role of T Lymphocytes -- Role of Cytokines -- Immunosuppression -- Immunoprophylaxis -- Host Immune Response to Leishmania Infection -- Human -- Mouse -- Hamster -- Cross-immunity Between Different Leishmania Species -- Adoptive Transfer of Immunity -- .3. Invade and Survival Strategy of Leishmania -- Host-Parasite Interaction -- Antigen Presentation and Immune Components Involved -- Survival and Evasion Strategies of Leishmania in Macrophages -- 4. Drugs and Diagnosis for Leishmaniasis -- Drugs Against Leishmaniasis -- Pentavalent Antimonials [Sb(V)] -- Amphotericin B -- Pentamidine -- Miltefosine (Hexadecylphosphocholine) -- Paromomycin (Aminosidine) -- Sitamaquine (WR 6026) -- Pamidronate -- Cutaneous Leishmaniasis (CL) -- Distribution -- Clinical Features -- Diffuse Cutaneous Leishmaniasis -- Recurring Cutaneous leishmaniasis -- Localised Cutaneous Leishmaniasis -- Treatment -- Mucocutaneous Leishmaniasis (MCL) -- Distribution -- Clinical Features -- Diagnosis -- Differential Diagnosis -- Treatment -- Prevention -- Visceral Leishmaniasis (VL) -- Diagnosis -- Treatment -- Post Kala-azar Dermal Leishmaniasis (PKDL) -- 5. Antimonials and Resistance -- Antimonials and Leishmaniasis -- Leishmanicidal Activity of SAG -- Interaction of SAG and Host Cell -- SAG Triggers RNI/ROI Generation -- SAG Activates Interleukin (IL) -- Interaction of Sb(V)/Sb(III) with Leishmania -- Mechanism of Action of SAG -- Antimonials Treatment, Failure and Resistance in Leishmania -- 6. Vaccines Against Leishmaniasis -- Vaccination Strategy and Vaccines Against Leishmanisis -- Live Vaccination -- Live-Attenuated Vaccines -- Killed Vaccines -- Fractionated/Subunit Vaccines -- Naked DNA Vaccines -- Recombinant and Synthetic Vaccines -- Non-protein Antigens as vaccine -- Anti-sandfly Saliva Components as Vaccine -- Adjuvants -- Delivery of Adjuvants -- Use of Cytokines as Adjuvant -- 7. Experimental Models for Leishmaniasis -- Mouse -- Hamster -- Dog |
| Summary |
Leishmania-related illnesses remain among the world s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis. Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population |
| Bibliography |
Includes bibliographical references (pages 75-83) |
| Notes |
English |
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Online resource; title from PDF title page (SpringerLink, viewed September 16, 2013) |
| Subject |
Leishmania.
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Leishmaniasis.
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Host-parasite relationships.
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Leishmania
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Host-Parasite Interactions
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Leishmania -- physiology
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Leishmaniasis
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Host-parasite relationships
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Leishmania
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Leishmaniasis
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| Form |
Electronic book
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| ISBN |
9781461488699 |
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1461488699 |
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1461488680 |
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9781461488682 |
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1306164753 |
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9781306164757 |
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