| Description |
1 online resource (xviii, 356 pages) |
| Series |
Cambridge molecular science |
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Cambridge molecular science series.
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| Contents |
880-01 Part I. Bulk Water: 1. Uniqueness of water -- 2. Anomalies of water -- 3. Dynamics of water: molecular motions and hydrogen bond breaking kinetics -- 4. Inherent structures of liquid water -- 5. pH of water -- Part II. Water in Biology: Dynamical View and Function: 6. Biological water -- 7. Explicit role of water in biological functions -- 8. Hydration of proteins -- 9. Can we understand protein hydration layer: lessons from computer simulations -- 10. Water in and around DNA and RNA -- 11. Role of water in protein-DNA interaction -- 12. Water surrounding lipid bilayers -- 13. Water in Darwin's world -- Part III. Water in Complex Chemical Systems: 14. Hydrophilic effects -- 15. Hydrophobic effects -- 16. Aqueous binary mixtures: amphiphilic effect -- 17. Water in and around micelles, reverse micelles and microemulsions -- 18. Water in carbon nanotubes -- Part IV. Bulk Water: Advanced Topics: 19. Entropy of water -- 20. Freezing of water into ice -- 21. Supercritical water -- 22. Microscopic approaches to understand water anomalies |
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880-01/(S Machine generated contents note: pt. I Bulk water -- 1. Uniqueness of water -- 1.1. Introduction -- 1.2. Molecular structure -- 1.3. Six unique features -- 1.4. Modeling of water -- 1.5. Conclusion -- 2. Anomalies of water -- 2.1. Anomalous properties -- 2.1.1. Density maximum -- 2.1.2. Isobaric specific heat (CP) -- 2.1.3. Isothermal compressibility (κT) -- 2.1.4. Coefficient of thermal expansion (αP) -- 2.1.5. Dynamic anomalies present at low temperature -- 2.2. Translational and orientational order -- 2.3. Temperature--density range of water anomalies -- 2.4. Conclusion -- Appendix 2.A Microscopic expressions of specific heat, isothermal compressibility, and coefficient of thermal expansion -- Appendix 2.B Quantification of spatial order in water -- 3. Dynamics of water: molecular motions and hydrogen-bond-breaking kinetics -- 3.1. Introduction -- 3.2. Timescales of translational and rotational motion -- 3.3. Jump reorientation motion in water -- 3.4. Effects of temperature on water motion -- 3.5. Translational diffusion -- 3.6. Hydrogen-bond lifetime dynamics -- 3.7. Vibrational dynamics of the O--H bond -- 3.8. Dielectric relaxation -- 3.9. Solvation dynamics -- 3.10. Ionic conductivity of rigid ions in water -- 3.11. Electron transfer reactions in water -- 3.12. Motion becomes collective at low temperature -- 3.13. Conclusion -- Appendix 3.A Rotational time correlation functions -- Appendix 3.B Quantification of hydrogen-bond lifetime dynamics -- 4. Inherent structures of liquid water -- 4.1. Introduction -- 4.2. Transition between inherent structures of water -- 4.3. Connected water cluster moves during transition -- 4.4. HB network restructuring -- 4.5. Coordination number fluctuation in inherent structure and corresponding dynamics in parent liquid -- 4.6. Low-energy excitations in liquid water -- 4.7. Conclusion -- 5. pH of water -- 5.1. Introduction -- 5.2. Temperature and pressure dependence of pH -- 5.3. Mechanism of autoionization -- 5.4. pH of blood -- 5.5. Food and blood pH -- 5.6. pH of seawater -- 5.7. Conclusion -- pt. II Water in biology -- 6. Biological water -- 6.1. Introduction -- 6.2. Relaxation measurements -- 6.3. Unique characteristics of biological water -- 6.4. Phenomenological models and simple theories -- 6.5. Protein--glass transition and hydration-layer dynamics -- 6.6. Protein aggregation and biological water -- 6.7. Conclusion -- Appendix 6 The dynamic exchange model -- 7. essential chemical for life processes: water in biological functions -- 7.1. Introduction -- 7.2. Role of water in enzyme kinetics -- 7.3. Role of water in drug--DNA intercalation -- 7.4. Role of water in the biological function of RNA -- 7.5. Water-mediated molecular recognition -- 7.6. Protein folding and protein association: role of biological water -- 7.7. Role of water in beta-amyloid aggregation in Alzheimer disease -- 7.7.1. Role of water in the early stages of oligomer formation -- 7.7.2. Role of water in the late stages of fibril growth -- 7.8. Role of water in photosynthesis -- 7.9. Conclusion -- 8. Hydration of proteins -- 8.1. Introduction -- 8.2. What is the thickness of the hydration shell-- 8.3. How structured is the water in the hydration shell of a protein-- 8.4. Orientational arrangement of water molecules at the surface -- 8.5. Dynamics of the protein hydration shell: experimental studies -- 8.5.1. Dielectric spectrum -- 8.5.2. Nuclear magnetic resonance studies -- 8.5.3. Quasi-elastic neutron-scattering experiments -- 8.5.4. Vibrational spectroscopy -- 8.5.5. Solvation dynamics -- 8.6. Conclusion -- Appendix 8.A Orientation of water molecules in the hydration layer -- 9. Understanding the protein hydration layer: lessons from computer simulations -- 9.1. Introduction -- 9.2. Molecular motion in the hydration layer -- 9.3. Hydrogen-bond lifetime dynamics -- 9.4. Computer simulation of solvation dynamics -- 9.5. Dielectric relaxation -- 9.6. Explanation of anomalous dynamics in the hydration layer -- 9.7. Protein--glass transition at 200 K: role of water dynamics -- 9.8. Free-energy barrier for escape of water molecules from protein hydration layer -- 9.9. Conclusion -- 10. Water in and around DNA and RNA -- 10.1. Introduction: the unique role of water in stabilizing DNA and RNA -- 10.2. Hydration of different constituents -- 10.3. Groove structure and water dynamics -- 10.4. Translational and rotational dynamics of water molecules in the grooves -- 10.5. Solvation dynamics -- 10.6. Entropy of groove water and dynamics -- 10.7. Correlation between diffusion and entropy: Adam--Gibbs relation -- 10.8. Sequence dependence of DNA hydration: spine of hydration in AT minor groove -- 10.9. Effects of nanoconfinement and surface-specific interactions -- 10.10. Water around RNA -- 10.10.1. Structure of water around RNA -- 10.10.2. Dynamics of water around RNA -- 10.11. Conclusion -- Appendix 10.A Hydrogen-bonding pattern around DNA -- 11. Protein--DNA interaction: the role of water as a facilitator -- 11.1. Introduction -- 11.2. Structural analysis of protein--DNA complex: classification of hydration water -- 11.3. Dynamics of water around a protein--DNA complex -- 11.4. Role of water in thermodynamics of protein--DNA interactions -- 11.5. Protein diffusion along DNA -- 11.6. Conclusion -- 12. Water surrounding lipid bilayers: its role as a lubricant -- 12.1. Introduction -- 12.2. Hydration of different constituents: phospholipids and buried proteins -- 12.3. Rugged energy landscape for water motion -- 12.4. Translational and rotational dynamics of water -- 12.5. Solvation dynamics -- 12.6. Transport of small molecules across the bilayer -- 12.7. Transport of large molecules across the bilayer -- 12.8. Electrostatic potential across the membrane -- 12.9. Conclusion -- 13. role of water in biochemical selection and protein synthesis -- 13.1. Introduction -- 13.2. Role of water in kinetic proofreading -- 13.2.1. Brief analysis of the Hopefield--Ninio approach to kinetic proofreading -- 13.2.2. Analysis of experimental results in the light of the Hopfield--Ninio formulation -- 13.2.3. Aminoacylation of tRNA during protein synthesis -- 13.2.4. tRNA selection in ribosome -- 13.2.5. DNA replication -- 13.3. Water as a lubricant of life -- 13.4. Conclusion -- pt |
| Summary |
Building up from microscopic basics to observed complex functions, this insightful monograph explains and describes how the unique molecular properties of water give rise to its structural and dynamical behaviour which in turn translates into its role in biological and chemical processes. The discussion of the biological functions of water details not only the stabilising effect of water in proteins and DNA, but also the direct role that water molecules themselves play in biochemical processes, such as enzyme kinetics, protein synthesis and drug-DNA interaction. The overview of the behaviour of water in chemical systems discusses hydrophilic, hydrophobic and amphiphilic effects, as well as the interactions of water with micelles, reverse micelles, microemulsions and carbon nanotubes. Supported by extensive experimental and computer simulation data, highlighting many of the recent advances in the study of water in complex systems, this is an ideal resource for anyone studying water at the molecular level |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Water in the body.
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Water chemistry.
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MEDICAL -- Physiology.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Water chemistry
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Water in the body
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| Form |
Electronic book
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| ISBN |
9781107416765 |
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1107416760 |
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9781139583947 |
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1139583948 |
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9781680159929 |
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1680159925 |
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