Clinical trials as research -- Why clinical trials are ethical -- Contexts for clinical trials -- Statistical perspectives -- Clinical trials as experimental designs -- Random error and bias -- Objectives and outcomes -- Translational clinical trials -- Dose-finding designs -- Sample size and power -- The study cohort -- Treatment allocation -- Treatment effects monitoring -- Counting subjects and events -- Estimating clinical effects -- Prognostic factor analyses -- Reporting and authorship -- Factorial designs -- Crossover designs -- Meta-analyses -- Misconduct and fraud in clinical research
Summary
The previous edition of this title has an excellent track record, and its continued comprehensive coverage is unparalleled by the competition. The author, who is renowned throughout the world, has significantly and thoroughly refined and retooled this edition
Bibliography
Includes bibliographical references (pages 613-658) and indexes
