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Title Cyclic nucleotide phosphodiesterases in health and disease / edited by Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay
Published Boca Raton : CRC Press/Taylor & Francis, ©2007


Description 1 online resource (713 pages, 38 unnumbered pages of plates) : illustrations (some color)
Contents Front cover; Preface; Editors; Contributors; Table of Contents; Introduction; Chapter 1. Cyclic Nucleotide Phosphodiesterase Superfamily; Chapter 2. Phosphodiesterase Isoforms- An Annotated List; Section A. Specific Phosphodiesterase Families-Regulation, Molecular and Biochemical Characteristics; Chapter 3. Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases; Chapter 4. PDE2 Structure and Functions; Chapter 5. Phosphodiesterase 3B: An Important Regulator of Energy Homeostasis; Chapter 6. Cellular Functions of PDE4 Enzymes
Chapter 7. Phosphodiesterase 5: Molecular Characteristics Relating to Structure, Function, and RegulationChapter 8. Photoreceptor Phosphodiesterase (PDE6): A G-Protein-Activated PDE Regulating Visual Excitation in Rod and Cone Photoreceptor Cells; Chapter 9. PDE7; Chapter 10. cAMP-Phosphodiesterase 8 Family; Chapter 11. PDE9; Chapter 12. PDE10A: A Striatum- Enriched, Dual-Substrate Phosphodiesterase; Chapter 13. PDE11; Section B. Nonmammalian Phosphodiesterases; Chapter 14. Protozoal Phosphodiesterases; Chapter 15. Studies of Phosphodiesterase Function Using Fruit Fly Genomics and Transgenics
Section C. Phosphodiesterases Functional Significance: Gene-Targeted Knockout StrategiesChapter 16. Insights into the Physiological Functions of PDE4 from Knockout Mice; Chapter 17. Regulation of cAMP Level by PDE3B-Physiological Implications in Energy Balance and Insulin Secretion; Section D. Compartmentation in Cyclic Nucleotide Signaling; Chapter 18. Heart Failure, Fibrosis, and Cyclic Nucleotide Metabolism in Cardiac Fibroblasts; Chapter 19. Role of A-Kinase Anchoring Proteins in the Compartmentation in Cyclic Nucleotide Signaling
Chapter 20. Role of Phosphodiesterases in Cyclic Nucleotide Compartmentation in Cardiac MyocytesSection E. Phosphodiesterases as Pharmacological Targets in Disease Processes; Chapter 21. Role of PDEs in Vascular Health and Disease: Endothelial PDEs and Angiogenesis; Chapter 22. Regulation of PDE Expression in Arteries: Role in Controlling Vascular Cyclic Nucleotide Signaling; Chapter 23. Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Diseases; Chapter 24. Role of Cyclic Nucleotide Phosphodiesterases in Heart Failure and Hypertension
Chapter 25. Molecular Determinants in Pulmonary Hypertension: The Role of PDE5Chapter 26. Role of PDE5 in Migraine; Chapter 27. Phosphodiesterase-4 as a Pharmacological Target Mediating Antidepressant and Cognitive Effects on Behavior; Chapter 28. Role of Phosphodiesterases in Apoptosis; Section F. Development of Specific Phosphodiesterase Inhibitors as Therapeutic Agents; Chapter 29. Crystal Structure of Phosphodiesterase Families and the Potential for Rational Drug Design; Chapter 30. Structure, Catalytic Mechanism, and Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases
Summary Phosphodiesterases in Health and Disease is a modern, comprehensive reference book on cyclic nucleotide phosophodiesterases (PDE) that will appeal to scientists in academia, the pharmaceutical industry, and related clinical disciplines. In the last 15 years, information relating to PDE genetics, physiological functions, roles in disease states, regulation, structure and interaction with pharmacologically active agents has burgeoned. This book covers the current information and its potential for future development. It describes the fundamental biochemical features of each of the known PDE famil
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cyclic nucleotide phosphodiesterases.
Phosphoric Diester Hydrolases -- physiology
Nucleotides, Cyclic -- physiology
Phosphodiesterase Inhibitors -- therapeutic use
MEDICAL -- Biochemistry.
Cyclic nucleotide phosphodiesterases
Form Electronic book
Author Beavo, Joe
Francis, Sharron H
Houslay, Miles D
ISBN 9781420020847