| Description |
1 online resource (223 pages) : illustrations |
| Contents |
History and biology of erythropoietin in hematopoietic and non-neural tissues / Giorgia Melli, Sanjay C. Keswani and Ahmet Hoke -- Expression of erythropoietin and its receptor in the central nervous system / Hugo Marti and Christian Bauer -- Erythropoietin and neuroprotection in the central nervous system : intracellular signaling pathways / Murat Digicaylioglu -- Regulation of erythropoietin expression in the nervous system : the hypoxia inducible factor / Juan C, Chavez and JoAnn M. Gensert -- Erythropoietin neuroprotection in the term and preterm infant : safety and efficacy / Eric J. Demers and Sandra E, Juul -- Erythropoietin for the treatment of acute ischemic stroke : preclinical rationale / Michael J. Renzi, Linda K, Jollijfe, Francis X. Farrell and Kenneth J, Rhodes -- Erythropoietin neuroprotection in the retina / Gundula Rohde, Mathias Bdhr and Jochen H. Weishaupt -- Erythropoietin for treatment of human brain disease : experience from proof-of-concept trials / Hannelore Ehrenreich and Anna-Leena Siren -- Erythropoietin in spinal cord injury / Michael Brines and Anthony Cerami -- Erythropoietin and neuroprotection in the peripheral nervous system : in vivo studies / W. M, Campana -- An endogenous pathway preventing axonal degeneration mediated by Schwann cell : derived erythropoietin / Sanjay C. Keswani and Ahmet Hoke -- Role of erythropoietin in inflammatory pathologies of the CNS / P. Ghezzi, P. Bigini, M, Mengozzi -- Development of non-erythropoietic erythropoietin variants for neuroprotection / Lars Torup and Marcel Leist |
| Summary |
Erythropoietin and the Nervous System is the first book of its kind to bring together researchers from many different disciplines of neuroscience to present a current state-of-the-art review of multiple aspects of erythropoietin research as it relates to the nervous system. Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with the relatively safety profile of this FDA-approved drug makes it an ideal candidate to take into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. This book should stimulate new research on erythropoietin and the nervous system and bring new investigators to the field. It will benefit scientists and clinicians interested in neuroprotection in the broadest sense |
| Analysis |
geneeskunde |
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medicine |
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volksgezondheid |
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public health |
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neurologie |
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neurology |
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chirurgie |
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surgery |
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psychiatrie |
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psychiatry |
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neurowetenschap |
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neuroscience |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| In |
Springer e-books |
| Subject |
Erythropoietin -- Physiological aspects
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Neuroprotective agents.
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Erythropoietin.
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Erythropoietin -- therapeutic use
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Nervous System Diseases -- drug therapy
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Erythropoietin
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Erythropoietin -- physiology
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Nervous System Diseases -- prevention & control
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Neuroprotective Agents
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MEDICAL -- Neuroscience.
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PSYCHOLOGY -- Neuropsychology.
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Erythropoietin -- therapeutic use.
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Nervous System Diseases -- drug therapy.
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Erythropoietin -- physiology.
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Nervous System Diseases -- prevention & control.
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Neuroprotective Agents.
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Erythropoietin -- Physiological aspects.
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Nervous system -- Surgery
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Neurology
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Neurosciences
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Psychiatry
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| Form |
Electronic book
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| Author |
Höke, Ahmet
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| ISBN |
9780387300115 |
|
0387300112 |
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0387300104 |
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9780387300108 |
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661070953X |
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9786610709533 |
|
