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Title Protein metabolism and homeostasis in aging / edited by Nektarios Tavernarakis
Published New York, N.Y. : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2010


Description 1 online resource (xxi, 249 pages) : illustrations
Series Advances in experimental medicine and biology ; v. 694
Advances in experimental medicine and biology ; v. 694.
Contents Synthesis, modification and turnover of proteins during aging / Suresh I.S. Rattan -- Regulation of mRNA translation as a conserved mechanism of longevity control / Ranjana Mehta [and others] -- Protein synthesis and the antagonistic pleiotropy hypothesis of aging / Pankaj Kapahi -- Proteasome function determines cellular homeostasis and the rate of aging / Niki Chondrogianni and Efstathios S. Gonos -- Autophagy and longevity : lessons from C. elegans / Kailiang Jia and Beth Levine -- Autophagy and aging : lessons from progeria models / Guillermo Mariño, Alvaro F. Fernández and Carlos López-Otín -- Regulation of protein turnover by longevity pathways / Tibor Vellai and Krisztina Takács-Vellai -- Protein metabolism and lifespan in Caenorhabditis elegans / Geert Depuydt, Jacques R. Vanfleteren and Bart P. Braeckman -- Mitochondrial protein quality control systems in aging and disease / Karin Luce, Andrea C. Weil and Heinz D. Osiewacz -- P38[superscript]MAPK in the senescence of human and murine fibroblasts / Florence Debacq-Chainiaux [and others] -- Protein homeostasis in models of aging and age-related conformational disease / Elise A. Kikis, Tali Gidalevitz and Richard I. Morimoto -- Roles for SUMO modification during senescence / Artemisia M. Andreou and Nektarios Tavernarakis -- Post-translational modification of cellular proteins by ubiquitin and ubiquitin-like molecules : role in cellular senescence and aging / Johannes Grillari, Regina Grillari-Voglauer and Pidder Jansen-Dürr -- Sensory influence on homeostasis and lifespan : molecules and circuits / Joy Alcedo, Wolfgang Maier and Queelim Ch'ng -- Regulation of muscle atrophy in aging and disease / Manlio Vinciguerra, Antonio Musaro and Nadia Rosenthal -- Confronting cellular heterogeneity in studies of protein metabolism and homeostasis in aging research / Louise Boisen and Peter Kristensen
Summary The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterized factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Proteins -- Metabolism.
Cells -- Aging.
Aging -- Physiological aspects
Biological models.
Cellular Senescence -- physiology
Aging -- physiology
Caenorhabditis elegans Proteins -- metabolism
Caenorhabditis elegans -- genetics
Homeostasis -- physiology
Models, Biological
Cellular Senescence
MEDICAL -- Biochemistry.
Sciences de la vie.
Aging -- Physiological aspects.
Cells -- Aging.
Proteins -- Metabolism.
Form Electronic book
Author Tavernarakis, Nektarios.
LC no. 2010021376
ISBN 9781441970022