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Title Adenosine deaminases acting on RNA (ADARs) and a-to-i editing / Charles E. Samuel, editor
Published Berlin ; New York : Springer, ©2012


Description 1 online resource (x, 238 pages)
Series Current topics in microbiology and immunology, 0070-217X ; v. 353
Current topics in microbiology and immunology ; v. 353.
Contents ADAR proteins : structure and catalytic mechanism / Rena A. Goodman, Mark R. Macbeth and Peter A. Beal -- ADAR proteins : double-stranded RNA and Z-DNA binding domains / Pierre Barraud and Frâedâeric H.-T. Allain -- Editing of neurotransmitter receptor and ion channel RNAs in the nervous system / Jennifer L. Hood and Ronald B. Emeson -- Modulation of microRNA expression and function by ADARs / Bjorn-Erik Wulff and Kazuko Nishikura -- Nuclear editing of mRNA 3'-UTRs / Ling-Ling Chen and Gordon G. Carmichael -- Control of ADAR1 editing of hepatitis delta virus RNAs / John L. Casey -- Bioinformatic approaches for identification of A-to-I editing sites / Eli Eisenberg -- ADARs : viruses and innate immunity / Charles E. Samuel -- Role of ADARs in mouse development / Carl R. Walkley, Brian Liddicoat and Jochen C. Hartner -- Regulation and functions of ADAR in Drosophila / Simona Paro, Xianghua Li, Mary A. O'Connell and Liam P. Keegan
Summary The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.¡ It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins
Analysis Medicine
Human physiology
Molecular Medicine
Bibliography Includes bibliographical references and index
Subject RNA-protein interactions.
Adenosine deaminase.
Adenosine Deaminase -- metabolism
RNA, Double-Stranded -- metabolism
RNA Editing
Adenosine Deaminase
SCIENCE -- Life Sciences -- Biochemistry.
Adenosine deaminase
RNA-protein interactions
Form Electronic book
Author Samuel, Charles E
ISBN 9783642228018