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Title Stress-induced mutagenesis / David Mittelman, editor
Published New York, NY : Springer, ©2013


Description 1 online resource
Contents Stress-Induced Mutagenesis in Bacteria / Ivan Matic -- Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress / Chandan Shee, P.J. Hastings, Susan M. Rosenberg -- Transcription-Mediated Mutagenic Processes / Eduardo Robleto, Holly A. Martin, Carmen Vallin -- Transposon Mutagenesis in Disease, Drug Discovery, and Bacterial Evolution / Zhongge Zhang, Jing Wang, Maksim A. Shlykov -- Hsp90 as a Capacitor of Both Genetic and Epigenetic Changes in the Genome During Cancer Progression and Evolution / Xiangyi Lu, Luan Wang, Vincent E. Sollars, Mark D. Garfinkel -- Inheritance of Stress-Induced Epigenetic Changes Mediated by the ATF-2 Family of Transcription Factors / Ki-Hyeon Seong, Toshio Maekawa, Shunsuke Ishii -- Microsatellite Repeats: Canaries in the Coalmine / Nimrat Chatterjee, Beatriz A. Santillan, John H. Wilson -- Genetic Instability Induced by Hypoxic Stress / Susan E. Scanlon, Peter M. Glazer -- Radiation-Induced Delayed Genome Instability and Hypermutation in Mammalian Cells / Christopher P. Allen, Akira Fujimori, Ryuichi Okayasu -- Radiation-Induced Bystander Effects and Stress-Induced Mutagenesis / Carmel Mothersill, Colin Seymour -- Stress Induced Mutagenesis, Genetic Diversification, and Cell Survival via Anastasis, the Reversal of Late Stage Apoptosis / Ho Lam Tang, Ho Man Tang, Denise J. Montell -- The Transgenerational Effects of Parental Exposure to Mutagens in Mammals / Yuri E. Dubrova -- Revisiting Mutagenesis in the Age of High-Throughput Sequencing / Subhajyoti De, R. Matthew Ward
Summary The discoveries of stress-induced mutation and epigenetic inheritance have challenged the claim of independence between the evolutionary forces of mutation and selection. In "Stress-Induced Mutagenesis", leading experts provide the key evidence for and the molecular details of stress-induced genetic and epigenetic mutation, integrating cross-disciplinary observations from a number of species and biological systems, including human. The observations have vast implications for evolutionary biology but also for human medicine. A comprehensive understanding of stress-induced mutagenesis and the processes underlying evolvability, will enable gains in the treatment and management of cancer, as well as other human disorders that result from damaged or unstable genomes
Analysis Medicine
Human genetics
biomedische wetenschappen
humane genetica
Medicine (General)
Geneeskunde (algemeen)
Notes Includes index
Bibliography Cludes bibliographical references
Notes English
In Springer eBooks
Subject Mutagenesis.
Epigenesis, Genetic
Stress, Physiological
SCIENCE -- Life Sciences -- Evolution.
medicines (material)
Form Electronic book
Author Mittelman, David
ISBN 9781461462804