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Title DNA and RNA modification enzymes : structure, mechanism, function, and evolution / [edited by] Henri Grosjean
Published Austin, Tex. : Landes Bioscience, ©2009


Description 1 online resource (653 pages)
Series Molecular biology intelligence unit
Molecular biology intelligence unit (Unnumbered : 2003)
Contents COVER. DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution; TITLE PAGE; Copyright ©2009 Landes Bioscience; Dedication; About the Editor ... HENRI GROSJEAN; CONTENTS; EDITOR AND CONTRIBUTORS; PREFACE; Acknowledgements; CHAPTER 1. Nucleic Acids Are Not Boring Long Polymers of Only Four Types of Nucleotides: A Guided Tour; CHAPTER 2. DNA Methylation: From Bug to Beast; CHAPTER 3. DNA Restriction-Modification Systems in Prokaryotes; CHAPTER 4. Experimental Approaches to Study DNA Base Flipping; CHAPTER 5. Molecular Modeling of Base Flipping in DNA
CHAPTER 6. M·HhaI and M·EcoRI: Paradigms for Understanding the Conformational Mechanisms of DNA MethyltransferasesCHAPTER 7. Mechanism and Evolution of DNA Recognition by DNA-(adenine N6)-Methyltransferases from the EcoDam Family; CHAPTER 8. Structures and Activities of Mammalian DNA Methyltransferases; CHAPTER 9. DNA Methylation and Human Diseases: An Overview; CHAPTER 10. Expanding the Chemical Repertoire of DNA Methyltransferases by Cofactor Engineering; CHAPTER 11. Studying Antibody Maturation Using Techniques for Detecting Uracils in DNA
CHAPTER 12. Enzymatic Formationof the Hypermodified DNA Base J (ß-D-Glucopyranosyloxymethyluracil)CHAPTER 13. DNA Demethylation; CHAPTER 14. Demethylation of DNA and RNA by AlkB Proteins; CHAPTER 15. The APOBEC1 Paradigm for Mammalian Cytidine Deaminases That Edit DNA and RNA; CHAPTER 16. Mechanism of Action and Structural Aspects of ADARS (A-to-I) and APOBEC-Related (C-to-U) Deaminases; CHAPTER 17. Structure of RNA Editing Substrates and Their Recognition by RNA Base Deaminase; CHAPTER 18. Biological Roles of ADARs
CHAPTER 19. The Interplay between RNA and DNA Modifications: Back to the RNA WorldCHAPTER 20. Folate-Dependent Thymidylate-Forming Enzymes: Parallels between DNA and RNA Metabolic Enzymes and Evolutionary Implications; CHAPTER 21. Folds and Functions of Domains in RNA Modification Enzymes; CHAPTER 22. Enzyme-RNA Substrate Recognition in RNA-Modifying Enzymes; CHAPTER 23. Molecular Basis of tRNA Processing Reactions; CHAPTER 24. RNA-Modifying Metalloenzymes; CHAPTER 25. Pseudouridine Formation, the Most Common Transglycosylation in RNA
CHAPTER 26. Enzymatic Formation of the 7-Deazaguanosine Hypermodified Nucleosides of tRNACHAPTER 27. Biogenesis and Functions of Thio-Compounds in Transfer RNA: Comparison of Bacterial and Eukaryotic Thiolation Machineries; CHAPTER 28. Enzymatic Formation of 5-Aminomethyl-Uridine Derivatives in tRNA: Functional and Evolutionary Implications; CHAPTER 29. Deciphering the Complex Enzymatic Pathway for Biosynthesis of Wyosine Derivatives in Anticodon of tRNA(Phe); CHAPTER 30. Multicomponent 2'-O-Ribose Methylation Machines: Evolving Box C/D RNP Structure and Function
Summary This volume is a timely and comprehensive description of the many facets of DNA and RNA modification-editing processes and to some extent repair mechanisms. Each chapter offers fundamental principles as well as up to date information on recent advances in the field (up to end 2008). They ended by a short 'conclusion and future prospect' section and an exhaustive list of 35 to up to 257 references (in average 87). Contributors are geneticists, structural enzymologists and molecular biologists working at the forefront of this exciting, fast-moving and diverse field of researches. This book will
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Nucleic acids -- Metabolism
DNA -- Methylation
Molecular evolution.
DNA Restriction-Modification Enzymes -- physiology
N-Glycosyl Hydrolases
DNA Methylation -- physiology
DNA Restriction-Modification Enzymes -- ultrastructure
Evolution, Molecular
RNA Processing, Post-Transcriptional -- physiology
SCIENCE -- Life Sciences -- Genetics & Genomics.
Molecular evolution
DNA -- Methylation
Nucleic acids -- Metabolism
Form Electronic book
Author Grosjean, Henri.
ISBN 9781441615589