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Title Cancer cytogenetics : methods and protocols / edited by John Swansbury
Published Totowa, N.J. : Humana Press, ©2003


Description 1 online resource (xi, 283 pages) : illustrations (some color)
Series Methods in molecular biology ; 220
Methods in molecular biology (Clifton, N.J.) ; v. 220
Contents Introduction / John Swansbury -- Cytogenetic Studies in Hematologic Malignancies : An Overview / John Swansbury -- The Myeloid Disorders : Background / John Swansbury -- Cytogenetic Techniques for Myeloid Disorders / John Swansbury -- Acute Lymphoblastic Leukemia : Background / John Swansbury -- Conventional Cytogenetic Techniques in the Diagnosis of Childhood Acute Lymphoblastic Leukemia / Susana C. Raimondi and Susan Mathew -- Chromosome Preparations from Bone Marrow in Acute Lymphoblastic Leukemia : Cytogenetic Techniques / Ann Watmore -- Lymphoid Disorders Other than Common Acute Lymphoblastic Leukemia : Background / John Swansbury -- Other Lymphoid Malignancies : Cytogenetic Techniques / John Swansbury -- Cytogenetic and Genetic Studies in Solid Tumors : Background / John Swansbury -- Human Solid Tumors : Cytogenetic Techniques / Pietro Polito [and others] -- Analysis and Interpretation of Cytogenetic Findings in Malignancies / John Swansbury -- Cytogenetic Studies Using FISH : Background / Toon Min and John Swansbury -- FISH Techniques / Toon Min -- FISH, CGH, and SKY in the Diagnosis of Childhood Acute Lymphoblastic Leukemia / Susan Mathew and Susana C. Raimondi -- Solving Problems in Multiplex FISH / Jon C. Strefford -- Some Difficult Choices in Cytogenetics / John Swansbury -- Introduction to the Analysis of the Human G-Banded Karyotype / John Swansbury
Summary Cytogenetic studies of malignancy have become an essential tool in the clinical management of cancer patients, but they are not uniformly utilized, even in well-developed countries. In Cancer Cytogenetics: Methods and Protocols, experienced cytogeneticists describe in step-by-step detail the key cytogenetic and FISH techniques used by modern clinical laboratories in the genetic analysis of human malignancies, as well as explain how best to interpret the results. The book's practical advice and methods are suitable for use at every level of expertise, including fully established laboratories, but with a sympathetic bias toward anyone considering setting up a new cytogenetics service. Here the reader will find not only elementary tutorials on the fundamentals of human karyotypes and chromosome analysis, but also detailed discussions on how laboratories may optimally upgrade their repertoire of available capabilities to include such newer complementary techniques as CGH, FISH, and M-FISH. Each protocol contains many novel ideas and time-saving techniques, expert commentary, tricks of the trade, alternative approaches, and suggestions that will help yield the results that clinicians want. Eminently practical for every stage of diagnostic service, Cancer Cytogenetics: Methods and Protocols offers hospital and other pathology laboratories a user-friendly collection of both standard and advanced techniques, all carefully designed to improve the diagnosis and clinical management of cancer patients today
Bibliography Includes bibliographical references and index
Notes English
Subject Cancer -- Genetic aspects -- Laboratory manuals
Neoplasms -- genetics
Cytogenetic Analysis
Hematologic Neoplasms -- genetics
Situ Hybridization, Fluorescence
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Cancer -- Genetic aspects
Genre/Form handbooks.
Handbooks and manuals
Laboratory manuals
Handbooks and manuals.
Laboratory manuals.
Manuels de laboratoire.
Guides et manuels.
Form Electronic book
Author Swansbury, John
ISBN 9781592593637