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Title Biomarkers for Alzheimer's disease drug development / edited by Robert Perneczky
Published New York : Humana Press : Springer, [2018]


Description 1 online resource (xv, 372 pages) : illustrations (some color)
Series Methods in molecular biology, 1940-6029 ; volume 1750
Methods in molecular biology (Clifton, N.J.) ; v. 1750. 1064-3745
Contents Epidemiology of Dementia: The Burden on Society, the Challenges for Research -- Population-based Approaches to Alzheimers Disease Prevention -- Systems Biology Methods for Alzheimers Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials -- CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform -- CSF N-glycomics using MALDI MS Techniques in Alzheimers Disease -- MicroRNA Profiling of Alzheimers Disease Cerebrospinal Fluid -- Validation of a Chemiluminescence Immunoassay for Measuring Amyloid- in Human Blood Plasma -- Mass Spectrometry-based Metabolomic Multiplatform for Alzheimers Disease Research -- Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases -- Functional Magnetic Resonance Imaging in Alzheimer Disease Drug Development -- Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies -- Hybrid PET-MRI in Alzheimers Disease Research -- Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers -- The use of 18F-FDG PET in the Diagnostic Workup of Alzheimers Dementia -- Quantification of Tau Load in Alzheimers Disease Clinical Trials Using Positron Emission Tomography -- Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach -- Unbiased Lipidomics and Metabolomics of Human Brain Samples -- Neuropathological Assessment as an Endpoint in Clinical Trial Design -- Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimers Disease Biomarker Discovery -- Telomere length shortening in Alzheimers disease procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study -- Quantifying miRNA Deregulation in Alzheimers Disease -- Imaging of Microglial Activation in Alzheimers Disease by [11C]PBR28 PET -- In Vivo Two-photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models -- Cognitive Assessment in Alzheimers Disease Clinical Trials -- Data Mining and Machine Learning Methods for Dementia Research
Summary This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimers disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimers disease, cutting-edge developments in neuropathology and their relevance for Alzheimers disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerProtocol, viewed March 7, 2018)
Subject Alzheimer's disease.
Biochemical markers.
Alzheimer Disease
Biomarkers, Pharmacological
Alzheimer's disease
Biochemical markers
Genre/Form Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Perneczky, Robert, editor.
ISBN 9781493977048