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Book Cover

Title Gadd45 stress sensor genes / Dan A. Liebermann, Barbara Hoffman, editors
Published New York : Springer, 2013


Description 1 online resource (x, 134 pages) : illustrations (some color)
Series Advances in Experimental Medicine and Biology, 0065-2598 ; 793
Advances in experimental medicine and biology ; 793. 0065-2598
Contents Gadd45 in stress signaling, cell cycle control and apoptosis -- Gadd45 in Modulation of Solid Tumors and Leukemia -- Gadd45 Proteins: Key players of repair-mediated DNA demethylation -- Gadd45 proteins in Immunity -- Gadd45 in the liver : Signal transduction and transcriptional mechanisms -- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics -- Gadd45 stress sensors in preeclampsia
Summary Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved
Notes Includes index
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed October 14, 2013)
In Springer eBooks
Subject Human molecular genetics.
Protein-protein interactions.
Cellular signal transduction.
Medical genetics.
Human genetics.
Genetics, Medical
Signal Transduction
MEDICAL -- Anatomy.
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
Medical genetics
Human genetics
Cellular signal transduction
Human molecular genetics
Protein-protein interactions
Form Electronic book
Author Liebermann, Dan A., editor
Hoffman, Barbara, editor
ISBN 9781461482895