Title Alzheimer's disease : methods and protocols / edited by Nigel M. Hooper

Published Totowa, N.J. : Humana Press, ©2000

Click on the following:
Springer eBooks

Copies

Description 1 online resource (xiv, 408 pages) : illustrations Series Methods in molecular medicine ; 32 Methods in molecular medicine ; 32. Contents Introduction to Alzheimer's disease / D. Allsop-The genetics of Alzheimer's disease / N. Brindle and P.S. George-Hyslop-Advances in methodology and current prospects for primary drug therapies for Alzheimer's disease / D.S. Knopman-Production and functional assays of recombinant secreted amyloid precursor protein (app) (sappalpha) / S.W. Barger-Quantifying abeta(1-40) and abeta (1-42) using sandwich-elisa / D.M. Skovronsky [and others]-Electrophoretic separation and immunoblotting of abeta(1-40) and abeta (1-42) / M. Staufenbiel and P.A. Paganetti-Abeta-induced proinflammatory cytokine release from differentiated human thp-1 monocytes / K.R. Brunden [and others]-Effects of the beta-amyloid peptide on membrane ion permeability / H.A. Pearson-Analysis of beta-amyloid peptide degradation in vitro / B. Cordell and A. Naidu-Posttranslational modifications of amyloid precursor protein : Ectodomain phosphorylation and sulfation / J. Walter and C. Haass-Posttranslational modifications of the amyloid precursor protein : Glycosylation / C. Liu [and others]-Using an amyloid precursor protein (app) reporter to characterize alpha-secretase / S.B. Roberts-Inhibition of alpha-secretase by zinc metalloproteinase inhibitors / S. Parvathy, A.J. Turner and N.M. Hooper-Development of neoepitope antibodies against the beta-secretase cleavage site in the amyloid precursor protein / C.W. Gray and E.H. Karran-Beta-secretase : Tissue culture studies of sequence specificity, inhibitors, and candidate enzymes / M. Citron-Using beta-secretase inhibitors to distiguish the generation of the abeta peptides terminating at val-40 and ala-42 / P.A. Paganetti and M. Staufenbiel-Designing animal models of Alzheimer's disease with amyloid precursor protein (app) transgenes / J.F. Loring-Phosphorylation of amyloid precursor protein (app) family proteins / T. Suzuki [and others]-Determining the transmembrane topology of the presenilins / G. Thinakaran and A. Doan-Normal proteolytic processing of the presenilins / H. Hartmann and B.A. Yankner-Apoptotic proteolytic cleavage of the presenilins by caspases / T.W. Kim-The phosphorylation of presenilin proteins / J. Walter-Interaction of the presenilins with the amyloid precursor protein (APP) / A. Weidemann [and others]-Distribution of presenilins and amyloid precursor protein (APP) in detergent-insoluble membrane domains / E.T. Parkin, A.J. Turner and N.M. Hooper-Characterization and use of monoclonal antibodies to tau and paired helical filament tau / P. Davies-Tau phosphorylation both in vitro and in cells / C.H. Reynolds, G.M. Gibb and S. Lovestone-Transglutaminase-catalyzed formation of Alzheimer-like insoluble complexes from recombinant tau / B.J. Balin and D.M. Appelt Summary With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert who uses it on a day-to-day basis. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagants and of amplification systems. Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based therapy. Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers todays diagnostic laboratories, basic and medical researchers, and active clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge Notes Source of title; title from Title page Bibliography Includes bibliographical references and index Issuing Body Digitization of Biomedprotocols made available on the world wide web by Humana Press Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL English digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Print version record In Springer Protocols Subject Alzheimer's disease -- Molecular aspects -- Laboratory manuals Alzheimer's disease -- Diagnosis -- Laboratory manuals Molecular diagnosis -- Laboratory manuals Proteins. Biology. Protein precursors. Amyloid. Brain -- Diseases. Life sciences. Mental illness. Central nervous system -- Diseases. Nervous system -- Diseases. Physical sciences. Diseases. Membrane proteins. Amyloid beta-protein precursor. Alzheimer's disease. Neurobehavioral disorders. Proteins Biology Amyloidogenic Proteins Tauopathies Dementia Protein Precursors Protease Nexins Amyloid Brain Diseases Proteinase Inhibitory Proteins, Secretory Amino Acids, Peptides, and Proteins Neurodegenerative Diseases Neurocognitive Disorders Biological Science Disciplines Mental Disorders Chemicals and Drugs Central Nervous System Diseases Nervous System Diseases Natural Science Disciplines Disciplines and Occupations Psychiatry and Psychology Disease Membrane Proteins Amyloid beta-Protein Precursor Genetics Alzheimer Disease protein. biology. biological sciences. mental disorders. physical sciences. HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Proteins Protein precursors Physical sciences Nervous system -- Diseases Mental illness Membrane proteins Life sciences Diseases Central nervous system -- Diseases Brain -- Diseases Biology Amyloid beta-protein precursor Amyloid Alzheimer's disease Alzheimer's disease -- Diagnosis Alzheimer's disease -- Molecular aspects Molecular diagnosis Wetenschappelijke technieken. Genre/Form Laboratory manuals Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Hooper, N. M. Humana Press. ISBN 9781592591954 1592591957 0585395071 9780585395074 1280821558 9781280821554 9786610821556 6610821550

OTHER TI Biomedprotocols

  Permalink