Limit search to available items
Book Cover

Title Amplification of chirality / volume editor, Kenso Soai ; with contributions by J.M. Brown [and others]
Published Berlin : Springer, ©2008


Description 1 online resource (vi, 205 pages) : illustrations
Series Topics in current chemistry ; 284
Topics in current chemistry ; 284.
Contents Asymmetric Autocatalysis with Amplification of Chirality -- Asymmetric Autocatalysis with Organozinc Complexes; Elucidation of the Reaction Pathway -- Kinetic Insight into Specific Features of the Autocatalytic Soai Reaction -- Rate Equation Approaches to Amplification of Enantiomeric Excess and Chiral Symmetry Breaking -- Helix Generation, Amplification, Switching, and Memory of Chromophoric Polymers
Summary Biomolecules in nature exhibit overwhelming one-handedness, often called homochirality, such as L-amino acids and D-sugars. Since the discovery of molecular chirality by Pasteur, the origins of chirality and the process le- ing to enantiopure biomolecules have attracted broad attention from many researchers. Several theories have been proposed for the origin of chirality in organic compounds, for example, left and right-circularly polarized light, sp- taneous absolute asymmetric synthesis, and chiral inorganic crystals such as quartz. However, the enantioenrichments induced by these mechanisms have been very low or even below detection levels. Thus, the process of ampli?cation of enantioenrichment is inevitable to reach enantiopure compounds. In 1953, Frank proposed a mechanism of asymmetric autocatalysis without mentioning any chemical structure. However, it then took over 40 years for us to discover asymmetric autocatalysis with ampli?cation of chirality in 1995. This book illustrates the recent aspects of ampli?cation of chirality by as- metric autocatalysis and by forming helical structures. The?rst four chapters summarize experimental asymmetric autocatalysis with ampli?cation of en- tiopurity, the mechanism of asymmetric autocatalysis examined by NMR and calculation, the computer simulation models of the reaction mechanism of asymmetric autocatalysis, and the theoretical models of ampli?cation of c- rality. The last chapter deals with the ampli?cation of chirality by the f- mation of helical structures. However, the ampli?cation of enantiopurity in non-autocatalytic asymmetric reaction and the ampli?cation by enantiomer separation involving crystallization or sublimation are beyond the scope of this book
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Chirality.
Circular dichroism.
Circular Dichroism
Science des matériaux.
Form Electronic book
Author Soai, Kenso.
Brown, John M., 1941-
ISBN 9783540778691