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Botulinum Toxin -- See Botulinum Toxins


Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS
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2 Botulinum toxin.   11
3 Botulinum toxin -- Administration : Botulinum neurotoxin : a guide to motor point injections / Chong Tae Kim  2022 1
4 Botulinum toxin -- Molecular aspects : Molecular aspects of botulinum neurotoxin / Keith A. Foster, editor  2014 1
5 Botulinum toxin -- Research : Molecular aspects of botulinum neurotoxin / Keith A. Foster, editor  2014 1
6 Botulinum toxin -- Therapeutic use.   38
7 Botulinum toxin -- Therapeutic use -- Handbooks, manuals, etc.   3
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Botulinum Toxins -- See Also Botulism


A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
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9 Botulinum Toxins.   4
10 Botulinum Toxins -- administration & dosage.   2
11 Botulinum Toxins -- chemistry : Molecular aspects of botulinum neurotoxin / Keith A. Foster, editor  2014 1
12 Botulinum Toxins -- metabolism : Molecular aspects of botulinum neurotoxin / Keith A. Foster, editor  2014 1
13 Botulinum Toxins -- pharmacology   5
14 Botulinum Toxins -- therapeutic use   15
15 Botulinum Toxins, Type A -- therapeutic use.   14
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