Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS
A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
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Clostridium botulinum -- pathogenicity : Treatments from toxins : the therapeutic potential of clostridial neurotoxins / edited by Keith A. Foster, Peter Hambleton, Clifford C. Shone
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS
Clostridium diseases -- Europe : Updates on Clostridioides difficile in Europe / Paola Mastrantonio, Maja Rupnik, editors
2024
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Clostridium diseases in animals. : Clostridial diseases of animals / [edited by] Francisco Alejandro Uzal, John Francis Prescott, J. Glenn Songer, Michel Robert Popoff
2016
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Clostridium diseases -- Prevention : Clostridium difficile infection in long-term care facilities : a clinician's guide / Teena Chopra, editor
2020
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Clostridium diseases -- Treatment : The 6 D's of fecal microbiota transplantation : a primer from decision to discharge and beyond / editors, Jessica R. Allegretti, Zain Kassam
Clostridium Infections -- therapy : The 6 D's of fecal microbiota transplantation : a primer from decision to discharge and beyond / editors, Jessica R. Allegretti, Zain Kassam
2021
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Clostridium Infections -- veterinary : Clostridial diseases of animals / [edited by] Francisco Alejandro Uzal, John Francis Prescott, J. Glenn Songer, Michel Robert Popoff
2016
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Clostridium -- pathogenicity : Clostridial diseases of animals / [edited by] Francisco Alejandro Uzal, John Francis Prescott, J. Glenn Songer, Michel Robert Popoff
2016
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Clostridium perfringens. : Microbial foodborne diseases : mechanisms of pathogenesis and toxin synthesis / edited by Jeffrey W. Cary, John E. Linz, Deepak Bhatnagar
