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Book Cover
Author Mir, Manzoor Ahmad, author

Title Developing costimulatory molecules for immunotherapy of diseases / Manzoor Ahmad Mir
Published London : Academic Press is an imprint of Elsevier, [2015]


Description 1 online resource : color illustrations
Contents Front Cover -- Developing Costimulatory Molecules for Immunotherapy of Diseases -- Copyright Page -- Dedication -- Contents -- About the Editor -- Preface -- Acknowledgments -- 1 Introduction to Costimulation and Costimulatory Molecules -- Introduction -- Costimulatory Molecules -- Two-Signal Model of T-cell Activation -- The B7 Family of Costimulatory Ligands -- CD80 Costimulatory Molecule -- CD86 Costimulatory Molecule -- CD80 and CD86 Expression Kinetics -- CD80 and CD86 Binding Kinetics to CD28 and CTLA-4
Different Oligomeric States of CD80 and CD86 -- PD-L1/B7-H1 Costimulatory Molecule -- B7-H2/B7RP-1/LICOS Costimulatory Molecule -- B7-DC/PD-L2 Costimulatory Molecule -- B7-H3 Costimulatory Molecule -- B7-H4 or B7x/B7S1 Costimulatory Molecule -- CD28 Molecule -- CTLA-4 Molecule -- ICOS Molecule -- The Programmed Death-1 -- CD40 Costimulatory Molecule -- CD40L/CD154 Costimulatory Molecule -- Pathways in the TNFR/TNF Family -- 4-1BB/4-1BBL -- OX40/OX40L -- HVEM/LIGHT -- ICOS, GITR, and CD27/CD70 -- Summary -- References
2 Concept of Reverse Costimulation and Its Role in Diseases -- Introduction -- Concept of Bidirectional Costimulation -- Reverse Costimulation of APCs -- Role of CD80 and CD86 in the Costimulation of B Cells -- Role of Bidirectional Costimulation in the Activation of DCs -- Role of Reverse Costimulation on Macrophages -- Application of Reverse Costimulation in Diseases -- Reverse Costimulation Through CD80 (B7-1) -- Reverse Costimulation Through CTLA-4 -- B7-DC Reverse Costimulation -- Reverse Costimulation Through CD40L/CD40 -- Reverse Signaling Through CD137L/CD137
Role of Reverse Costimulation in Cancer -- References -- 3 Costimulation Immunotherapy in Infectious Diseases -- Introduction -- Costimulation Biology Modulation by Pathogens -- Modulation of Costimulatory Molecules by Viruses -- Modulation of Costimulatory Molecules by Bacteria -- Modulation of Costimulatory Molecules by Protozoan Parasites -- Costimulatory Molecules in Therapeutic Vaccination -- Therapeutic Vaccination Using Costimulatory Molecules in HIV -- B7 Costimulatory Molecules in Infectious Diseases -- Costimulatory Molecules in Allergies and Asthma
Involvement of the B7:CD28 Family Molecules in the Regulation of Allergic Diseases -- Regulation of the Immune Responses to Pathogens Through Costimulatory Molecules -- Expression of Coinhibitory Molecules on Effector T Cells -- Role of Coinhibitory Molecules in the Contraction of the Effector Phase of Immune Responses -- Functional Exhaustion and Loss of Effector Functions -- Potential Therapeutic Applications of Costimulatory Molecules in Infections -- Summary -- References -- 4 Costimulation Immunotherapy in Allergies and Asthma -- Introduction
Summary Developing Costimulatory Molecules for Immunotherapy of Diseases highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy using either humanized antibodies against CD80, CD86, and other costimulatory molecules or CD28 fusinogenic proteins in the treatment of diseases, including allergies, asthma, rheumatoid arthritis, multiple sclerosis, lupus nephritis, severe psoriasis, vulgaris tuberculosis, thopoid, transplantation therapeutic, cancer, and inflammation. The text aims to provide the latest information on the complex roles an
Bibliography Includes bibliographical references and index
Notes English
Online resource; title from PDF title page (Ebsco, viewed June 3, 2015)
Subject Immunologic diseases -- Treatment
Cellular therapy.
Costimulatory and Inhibitory T-Cell Receptors
Cell- and Tissue-Based Therapy
HEALTH & FITNESS -- Diseases -- Immune System.
MEDICAL -- Immunology.
Cellular therapy
Immunologic diseases -- Treatment
Form Electronic book
ISBN 9780128026755